Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome"

Jos W M van der Meer; Mihai G Netea; Jochem M D Galama; Frank J M van Kuppeveld

doi:10.1126/science.1183906

Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome"

Jos W M van der Meer, Mihai G Netea, Jochem M D Galama, Frank J M van Kuppeveld

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Lombardi et al. (Reports, 23 October 2009, p. 585) reported detection of the human gammaretrovirus XMRV in the blood cells of patients with chronic fatigue syndrome (CFS). However, the patient description provided was incomplete. The inclusion of patients from a "CFS outbreak" previously linked with a viral infection, without confirmation in sporadic CFS cases, casts doubt on the role of XMRV in the pathogenesis of CFS.

Original language	English
Pages (from-to)	825; author reply 825
Journal	Science
Volume	328
Issue number	5980
DOIs	https://doi.org/10.1126/science.1183906
Publication status	Published - 2010

Keywords

Blood Cells
Cohort Studies
Cytokines
Disease Outbreaks
Epidemiologic Research Design
Fatigue Syndrome, Chronic
Gammaretrovirus
Humans
Retroviridae Infections
Tumor Virus Infections

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10.1126/science.1183906

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@article{98d27da15ed348869d41aa74b65d21a3,

title = "Comment on {"}Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome{"}",

abstract = "Lombardi et al. (Reports, 23 October 2009, p. 585) reported detection of the human gammaretrovirus XMRV in the blood cells of patients with chronic fatigue syndrome (CFS). However, the patient description provided was incomplete. The inclusion of patients from a {"}CFS outbreak{"} previously linked with a viral infection, without confirmation in sporadic CFS cases, casts doubt on the role of XMRV in the pathogenesis of CFS.",

keywords = "Blood Cells, Cohort Studies, Cytokines, Disease Outbreaks, Epidemiologic Research Design, Fatigue Syndrome, Chronic, Gammaretrovirus, Humans, Retroviridae Infections, Tumor Virus Infections",

author = "{van der Meer}, {Jos W M} and Netea, {Mihai G} and Galama, {Jochem M D} and {van Kuppeveld}, {Frank J M}",

year = "2010",

doi = "10.1126/science.1183906",

language = "English",

volume = "328",

pages = "825; author reply 825",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5980",

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TY - JOUR

T1 - Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome"

AU - van der Meer, Jos W M

AU - Netea, Mihai G

AU - Galama, Jochem M D

AU - van Kuppeveld, Frank J M

PY - 2010

Y1 - 2010

N2 - Lombardi et al. (Reports, 23 October 2009, p. 585) reported detection of the human gammaretrovirus XMRV in the blood cells of patients with chronic fatigue syndrome (CFS). However, the patient description provided was incomplete. The inclusion of patients from a "CFS outbreak" previously linked with a viral infection, without confirmation in sporadic CFS cases, casts doubt on the role of XMRV in the pathogenesis of CFS.

AB - Lombardi et al. (Reports, 23 October 2009, p. 585) reported detection of the human gammaretrovirus XMRV in the blood cells of patients with chronic fatigue syndrome (CFS). However, the patient description provided was incomplete. The inclusion of patients from a "CFS outbreak" previously linked with a viral infection, without confirmation in sporadic CFS cases, casts doubt on the role of XMRV in the pathogenesis of CFS.

KW - Blood Cells

KW - Cohort Studies

KW - Cytokines

KW - Disease Outbreaks

KW - Epidemiologic Research Design

KW - Fatigue Syndrome, Chronic

KW - Gammaretrovirus

KW - Humans

KW - Retroviridae Infections

KW - Tumor Virus Infections

U2 - 10.1126/science.1183906

DO - 10.1126/science.1183906

M3 - Article

C2 - 20466904

SN - 0036-8075

VL - 328

SP - 825; author reply 825

JO - Science

JF - Science

IS - 5980

ER -

Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome"

Abstract

Keywords

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