Abstract
Water insoluble bioactive molecules with very high melting temperature and low solubility in water are difficult to formulate in food products. We demonstrate the synthesis of nanoscale particles from steroid glycosides using a facile liquid antisolvent precipitation method in the presence of various food grade stabilizers. Colloidal particles with sizes well below 200 nm are prepared from steroid glycosides containing extracts, as well as mixtures with phytosterol. In the mixtures, the formation of the typical for the phytosterol rod-like particles is suppressed. Particle size and structure are investigated by electron microscopy and dynamic light scattering. Due to the presence of surface charge and steric stabilization, colloidal particles do not display aggregation and are stable for a period of longer than one year. The results of this study are important for the formulation and delivery of steroid glycoside and phytosterol bioactive molecules in the fields of food, nutraceuticals, and medical applications.
| Original language | English |
|---|---|
| Pages (from-to) | 485-490 |
| Number of pages | 6 |
| Journal | Food and Function |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2018 |
Bibliographical note
Funding Information:We thank B. A. Graf, S. L. Abrahamse, and G. S. M. J. E. Duchateau for stimulating discussions. This research work was partially funded by the Dutch Ministry of Economic Affairs through the Food & Nutrition Delta 2 Program (grant DFN0642300) and by NanoNextNL (consortium of Dutch government and 130 other partners).
Publisher Copyright:
© 2018 The Royal Society of Chemistry.
Funding
We thank B. A. Graf, S. L. Abrahamse, and G. S. M. J. E. Duchateau for stimulating discussions. This research work was partially funded by the Dutch Ministry of Economic Affairs through the Food & Nutrition Delta 2 Program (grant DFN0642300) and by NanoNextNL (consortium of Dutch government and 130 other partners).