Colloidal emulsion based delivery systems for steroid glycosides

Sergey M. Melnikov; Alois K. Popp; Song Miao; Ashok R. Patel; Leonard M. Flendrig; Krassimir P. Velikov

doi:10.1016/j.jff.2016.11.014

Colloidal emulsion based delivery systems for steroid glycosides

Sergey M. Melnikov, Alois K. Popp, Song Miao, Ashok R. Patel, Leonard M. Flendrig, Krassimir P. Velikov^*

^*Corresponding author for this work

Sub Soft Condensed Matter

Unilever

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Water insoluble bioactive molecules with limited solubility in common triglyceride are difficult to formulate in colloidal form. We demonstrate the fabrication and characterization of nanoscale diacylglycerol oil-in-water emulsions containing high levels (20 wt%) of steroid glycosides stabilized by food grade emulsifiers. The emulsions were produced using ultra high pressure (120 MPa) homogenization with average droplet sizes as small as 80 nm. The nanoscale emulsions were stabilized using food grade surfactants, surface active biopolymers and proteins. Due to amphiphilic nature of steroid glycosides molecule and higher polarity of the diacylglycerol rich oils used as solvents, it was possible to prepare stable emulsifier-free emulsions. The emulsions displayed very good stability against Ostwald ripening, creaming and coalescence. The emulsions were followed in time and were found stable for more than one year. In the presence of some sugars, the emulsions can be freeze-dried and form readily water dispersible powders without significant coalescence.

Original language	English
Pages (from-to)	90-95
Number of pages	6
Journal	Journal of Functional Foods
Volume	28
DOIs	https://doi.org/10.1016/j.jff.2016.11.014
Publication status	Published - 1 Jan 2017

Bibliographical note

Funding Information:
We thank J.W.M. Seijen ten Hoorn, A. Strom, J. von Harras, B. Graf, G.S.M.J. Duchateau, and L. Abrahamse for stimulating discussions. W. Frith and J. Henry are acknowledged for their assistance with the homogenizer. This research work was partially funded by the Dutch Ministry of Economic Affairs through the Food & Nutrition Delta 2 Program (grant DFN0642300 ) and by NanoNextNL (consortium of Dutch government and 130 other partners).

Publisher Copyright:
© 2016

Funding

We thank J.W.M. Seijen ten Hoorn, A. Strom, J. von Harras, B. Graf, G.S.M.J. Duchateau, and L. Abrahamse for stimulating discussions. W. Frith and J. Henry are acknowledged for their assistance with the homogenizer. This research work was partially funded by the Dutch Ministry of Economic Affairs through the Food & Nutrition Delta 2 Program (grant DFN0642300 ) and by NanoNextNL (consortium of Dutch government and 130 other partners).

Keywords

Colloids
Delivery
Emulsions
Nanoemulsions
Steroid glycosides

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10.1016/j.jff.2016.11.014

1-s2.0-S1756464616303565-mainFinal published version, 963 KBLicence: Taverne

Cite this

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title = "Colloidal emulsion based delivery systems for steroid glycosides",

abstract = "Water insoluble bioactive molecules with limited solubility in common triglyceride are difficult to formulate in colloidal form. We demonstrate the fabrication and characterization of nanoscale diacylglycerol oil-in-water emulsions containing high levels (20 wt%) of steroid glycosides stabilized by food grade emulsifiers. The emulsions were produced using ultra high pressure (120 MPa) homogenization with average droplet sizes as small as 80 nm. The nanoscale emulsions were stabilized using food grade surfactants, surface active biopolymers and proteins. Due to amphiphilic nature of steroid glycosides molecule and higher polarity of the diacylglycerol rich oils used as solvents, it was possible to prepare stable emulsifier-free emulsions. The emulsions displayed very good stability against Ostwald ripening, creaming and coalescence. The emulsions were followed in time and were found stable for more than one year. In the presence of some sugars, the emulsions can be freeze-dried and form readily water dispersible powders without significant coalescence.",

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AU - Velikov, Krassimir P.

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N2 - Water insoluble bioactive molecules with limited solubility in common triglyceride are difficult to formulate in colloidal form. We demonstrate the fabrication and characterization of nanoscale diacylglycerol oil-in-water emulsions containing high levels (20 wt%) of steroid glycosides stabilized by food grade emulsifiers. The emulsions were produced using ultra high pressure (120 MPa) homogenization with average droplet sizes as small as 80 nm. The nanoscale emulsions were stabilized using food grade surfactants, surface active biopolymers and proteins. Due to amphiphilic nature of steroid glycosides molecule and higher polarity of the diacylglycerol rich oils used as solvents, it was possible to prepare stable emulsifier-free emulsions. The emulsions displayed very good stability against Ostwald ripening, creaming and coalescence. The emulsions were followed in time and were found stable for more than one year. In the presence of some sugars, the emulsions can be freeze-dried and form readily water dispersible powders without significant coalescence.

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Colloidal emulsion based delivery systems for steroid glycosides

Abstract

Bibliographical note

Funding

Keywords

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