TY - JOUR
T1 - Clinical presentation of young people (10-24 years old) with brain tumors
T2 - results from the international MOBI-Kids study
AU - Zumel-Marne, Angela
AU - Kundi, Michael
AU - Castaño-Vinyals, Gemma
AU - Alguacil, Juan
AU - Petridou, Eleni Th
AU - Georgakis, Marios K
AU - Morales-Suárez-Varela, Maria
AU - Sadetzki, Siegal
AU - Piro, Sara
AU - Nagrani, Rajini
AU - Filippini, Graziella
AU - Hutter, Hans-Peter
AU - Dikshit, Rajesh
AU - Woehrer, Adelheid
AU - Maule, Milena
AU - Weinmann, Tobias
AU - Krewski, Daniel
AU - T Mannetje, Andrea
AU - Momoli, Franco
AU - Lacour, Brigitte
AU - Mattioli, Stefano
AU - Spinelli, John J
AU - Ritvo, Paul
AU - Remen, Thomas
AU - Kojimahara, Noriko
AU - Eng, Amanda
AU - Thurston, Angela
AU - Lim, Hyungryul
AU - Ha, Mina
AU - Yamaguchi, Naohito
AU - Mohipp, Charmaine
AU - Bouka, Evdoxia
AU - Eastman, Chelsea
AU - Vermeulen, Roel
AU - Kromhout, Hans
AU - Cardis, Elisabeth
PY - 2020
Y1 - 2020
N2 - INTRODUCTION: We used data from MOBI-Kids, a 14-country international collaborative case-control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24).METHODS: Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location.RESULTS: Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and 'non-neuroepithelial' tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/vomiting was the only combination of symptoms that exceeded a cutoff of 50%, with a joint occurrence of 67%. Overall, the median time from first symptom to diagnosis was 1.42 months (IQR 0.53-4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays.CONCLUSIONS: This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.
AB - INTRODUCTION: We used data from MOBI-Kids, a 14-country international collaborative case-control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24).METHODS: Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location.RESULTS: Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and 'non-neuroepithelial' tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/vomiting was the only combination of symptoms that exceeded a cutoff of 50%, with a joint occurrence of 67%. Overall, the median time from first symptom to diagnosis was 1.42 months (IQR 0.53-4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays.CONCLUSIONS: This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.
KW - Brain tumor
KW - Diagnosis
KW - Symptom
KW - Central nervous system tumor
KW - Clinical characteristic
U2 - 10.1007/s11060-020-03437-4
DO - 10.1007/s11060-020-03437-4
M3 - Article
C2 - 32124185
SN - 0167-594X
VL - 147
SP - 427
EP - 440
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
ER -