Clinical outcome after traumatic spinal fractures in patients with ankylosing spinal disorders compared with control patients.

L.A. Westerveld, J.C. van Bemmel, W.J.A. Dhert, F.C. Öner, J.J. Verlaan

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    Background context

    The clinical outcome of patients with ankylosing spinal disorders (ASDs) sustaining a spinal fracture has been described to be worse compared with the general trauma population.

    Purpose

    To investigate clinical outcome (neurologic deficits, complications, and mortality) after spinal injury in patients with ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH) compared with control patients.

    Study design

    Retrospective cohort study.

    Patient sample

    All patients older than 50 years and admitted with a traumatic spinal fracture to the Emergency Department of the University Medical Center Utrecht, the Netherlands, a regional level-1 trauma center and tertiary referral spine center.

    Outcome measures

    Data on comorbidity (Charlson comorbidity score), mechanism of trauma, fracture characteristics, neurologic deficit, complications, and in-hospital mortality were collected from medical records.

    Methods

    With logistic regression analysis, the association between the presence of an ASD and mortality was investigated in relation to other known risk factors for mortality.

    Results

    A total of 165 patients met the inclusion criteria; 14 patients were diagnosed with AS (8.5%), 40 patients had DISH (24.2%), and 111 patients were control patients (67.3%). Ankylosing spinal disorder patients were approximately five years older than control patients and predominantly of male gender. The Charlson comorbidity score did not significantly differ among the groups, but Type 2 diabetes mellitus and obesity were more prevalent among DISH patients. In many AS and DISH cases, fractures resulted from low-energy trauma and showed a hyperextension configuration. Patients with AS and DISH were frequently admitted with a neurologic deficit (57.1% and 30.0%, respectively) compared with controls (12.6%; p=.002), which did not improve in the majority of cases. In AS and DISH patients, complication and mortality rates were significantly higher than in controls. Logistic regression analysis showed the parameters age and presence of DISH to be independently, statistically significantly related to mortality.

    Conclusions

    Many patients with AS and DISH showed unstable (hyperextension) fracture configurations and neurologic deficits. Complication and mortality rates were higher in patients with ASD compared with control patients. Increasing age and presence of DISH are predictors of mortality after a spinal fracture.
    Original languageEnglish
    Pages (from-to)729-740
    Number of pages12
    JournalThe Spine Journal
    Volume14
    Issue number5
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Diffuse idiopathic skeletal hyperostosis (DISH)
    • Ankylosing spondylitis (AS)
    • Ankylosis
    • Trauma
    • Spine fracture

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