Abstract
Cleavage of the mouse hepatitis coronavirus strain A59 spike protein was blocked in a concentration-dependent manner by a peptide furin inhibitor, indicating that furin or a furin-like enzyme is responsible for this process. While cell-cell fusion was clearly affected by preventing spike protein cleavage, virus-cell fusion was not, indicating that these events have different requirements.
| Original language | English |
|---|---|
| Pages (from-to) | 6048-54 |
| Number of pages | 7 |
| Journal | Journal of Virology |
| Volume | 78 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Jun 2004 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Endocytosis
- Furin
- Hydrogen-Ion Concentration
- Membrane Fusion
- Membrane Glycoproteins
- Spike Glycoprotein, Coronavirus
- Viral Envelope Proteins
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