Circulating immune/inflammation markers in Chinese workers occupationally exposed to formaldehyde

Wei Jie Seow; Luoping Zhang; Roel Vermeulen; Xiaojiang Tang; Wei Hu; Bryan A Bassig; Zhiying Ji; Meredith S Shiels; Troy J Kemp; Min Shen; Chuangyi Qiu; Boris Reiss; Laura E Beane Freeman; Aaron Blair; Christopher Kim; Weihong Guo; Cuiju Wen; Laiyu Li; Ligia A Pinto; Hanlin Huang; Martyn T Smith; Allan Hildesheim; Nathaniel Rothman; Qing Lan

doi:10.1093/carcin/bgv055

Circulating immune/inflammation markers in Chinese workers occupationally exposed to formaldehyde

Wei Jie Seow
, Luoping Zhang
, Roel Vermeulen
, Xiaojiang Tang
, Wei Hu
, Bryan A Bassig
, Zhiying Ji
, Meredith S Shiels
, Troy J Kemp
, Min Shen
, Chuangyi Qiu
, Boris Reiss
, Laura E Beane Freeman
, Aaron Blair
, Christopher Kim
, Weihong Guo
, Cuiju Wen
, Laiyu Li
, Ligia A Pinto
, Hanlin Huang

Martyn T Smith, Allan Hildesheim, Nathaniel Rothman, Qing Lan

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Formaldehyde has been classified as a human myeloid leukemogen. However, the mechanistic basis for this association is still debated.

OBJECTIVES: We aimed to evaluate whether circulating immune/inflammation markers were altered in workers occupationally exposed to formaldehyde.

METHODS: Using a multiplexed bead-based assay, we measured serum levels of 38 immune/inflammation markers in a cross-sectional study of 43 formaldehyde-exposed and 51 unexposed factory workers in Guangdong, China. Linear regression models adjusting for potential confounders were used to compare marker levels in exposed and unexposed workers.

RESULTS: We found significantly lower circulating levels of two markers among exposed factory workers compared with unexposed controls that remained significant after adjusting for potential confounders and multiple comparisons using a false discovery rate of 10%, including chemokine (C-X-C motif) ligand 11 (36.2 pg/ml in exposed versus 48.4 pg/ml in controls, P = 0.0008) and thymus and activation regulated chemokine (52.7 pg/ml in exposed versus 75.0 pg/ml in controls, P = 0.0028), suggesting immunosuppression among formaldehyde-exposed workers.

CONCLUSIONS: Our findings are consistent with recently emerging understanding that immunosuppression might be associated with myeloid diseases. These findings, if replicated in a larger study, may provide insights into the mechanisms by which formaldehyde promotes leukemogenesis.

Original language	English
Pages (from-to)	852-857
Number of pages	6
Journal	Carcinogenesis
Volume	36
Issue number	8
DOIs	https://doi.org/10.1093/carcin/bgv055
Publication status	Published - Aug 2015

Bibliographical note

Published by Oxford University Press 2015.

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Seow, W. J., Zhang, L., Vermeulen, R., Tang, X., Hu, W., Bassig, B. A., Ji, Z., Shiels, M. S., Kemp, T. J., Shen, M., Qiu, C., Reiss, B., Beane Freeman, L. E., Blair, A., Kim, C., Guo, W., Wen, C., Li, L., Pinto, L. A., ... Lan, Q. (2015). Circulating immune/inflammation markers in Chinese workers occupationally exposed to formaldehyde. Carcinogenesis, 36(8), 852-857. https://doi.org/10.1093/carcin/bgv055

@article{646f74e94eb64381af12bf7cfbc210c1,

title = "Circulating immune/inflammation markers in Chinese workers occupationally exposed to formaldehyde",

abstract = "BACKGROUND: Formaldehyde has been classified as a human myeloid leukemogen. However, the mechanistic basis for this association is still debated.OBJECTIVES: We aimed to evaluate whether circulating immune/inflammation markers were altered in workers occupationally exposed to formaldehyde.METHODS: Using a multiplexed bead-based assay, we measured serum levels of 38 immune/inflammation markers in a cross-sectional study of 43 formaldehyde-exposed and 51 unexposed factory workers in Guangdong, China. Linear regression models adjusting for potential confounders were used to compare marker levels in exposed and unexposed workers.RESULTS: We found significantly lower circulating levels of two markers among exposed factory workers compared with unexposed controls that remained significant after adjusting for potential confounders and multiple comparisons using a false discovery rate of 10\%, including chemokine (C-X-C motif) ligand 11 (36.2 pg/ml in exposed versus 48.4 pg/ml in controls, P = 0.0008) and thymus and activation regulated chemokine (52.7 pg/ml in exposed versus 75.0 pg/ml in controls, P = 0.0028), suggesting immunosuppression among formaldehyde-exposed workers.CONCLUSIONS: Our findings are consistent with recently emerging understanding that immunosuppression might be associated with myeloid diseases. These findings, if replicated in a larger study, may provide insights into the mechanisms by which formaldehyde promotes leukemogenesis.",

author = "Seow, \{Wei Jie\} and Luoping Zhang and Roel Vermeulen and Xiaojiang Tang and Wei Hu and Bassig, \{Bryan A\} and Zhiying Ji and Shiels, \{Meredith S\} and Kemp, \{Troy J\} and Min Shen and Chuangyi Qiu and Boris Reiss and \{Beane Freeman\}, \{Laura E\} and Aaron Blair and Christopher Kim and Weihong Guo and Cuiju Wen and Laiyu Li and Pinto, \{Ligia A\} and Hanlin Huang and Smith, \{Martyn T\} and Allan Hildesheim and Nathaniel Rothman and Qing Lan",

note = "Published by Oxford University Press 2015.",

year = "2015",

month = aug,

doi = "10.1093/carcin/bgv055",

language = "English",

volume = "36",

pages = "852--857",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "8",

}

Seow, WJ, Zhang, L, Vermeulen, R, Tang, X, Hu, W, Bassig, BA, Ji, Z, Shiels, MS, Kemp, TJ, Shen, M, Qiu, C, Reiss, B, Beane Freeman, LE, Blair, A, Kim, C, Guo, W, Wen, C, Li, L, Pinto, LA, Huang, H, Smith, MT, Hildesheim, A, Rothman, N & Lan, Q 2015, 'Circulating immune/inflammation markers in Chinese workers occupationally exposed to formaldehyde', Carcinogenesis, vol. 36, no. 8, pp. 852-857. https://doi.org/10.1093/carcin/bgv055

TY - JOUR

T1 - Circulating immune/inflammation markers in Chinese workers occupationally exposed to formaldehyde

AU - Seow, Wei Jie

AU - Zhang, Luoping

AU - Vermeulen, Roel

AU - Tang, Xiaojiang

AU - Hu, Wei

AU - Bassig, Bryan A

AU - Ji, Zhiying

AU - Shiels, Meredith S

AU - Kemp, Troy J

AU - Shen, Min

AU - Qiu, Chuangyi

AU - Reiss, Boris

AU - Beane Freeman, Laura E

AU - Blair, Aaron

AU - Kim, Christopher

AU - Guo, Weihong

AU - Wen, Cuiju

AU - Li, Laiyu

AU - Pinto, Ligia A

AU - Huang, Hanlin

AU - Smith, Martyn T

AU - Hildesheim, Allan

AU - Rothman, Nathaniel

AU - Lan, Qing

N1 - Published by Oxford University Press 2015.

PY - 2015/8

Y1 - 2015/8

N2 - BACKGROUND: Formaldehyde has been classified as a human myeloid leukemogen. However, the mechanistic basis for this association is still debated.OBJECTIVES: We aimed to evaluate whether circulating immune/inflammation markers were altered in workers occupationally exposed to formaldehyde.METHODS: Using a multiplexed bead-based assay, we measured serum levels of 38 immune/inflammation markers in a cross-sectional study of 43 formaldehyde-exposed and 51 unexposed factory workers in Guangdong, China. Linear regression models adjusting for potential confounders were used to compare marker levels in exposed and unexposed workers.RESULTS: We found significantly lower circulating levels of two markers among exposed factory workers compared with unexposed controls that remained significant after adjusting for potential confounders and multiple comparisons using a false discovery rate of 10%, including chemokine (C-X-C motif) ligand 11 (36.2 pg/ml in exposed versus 48.4 pg/ml in controls, P = 0.0008) and thymus and activation regulated chemokine (52.7 pg/ml in exposed versus 75.0 pg/ml in controls, P = 0.0028), suggesting immunosuppression among formaldehyde-exposed workers.CONCLUSIONS: Our findings are consistent with recently emerging understanding that immunosuppression might be associated with myeloid diseases. These findings, if replicated in a larger study, may provide insights into the mechanisms by which formaldehyde promotes leukemogenesis.

AB - BACKGROUND: Formaldehyde has been classified as a human myeloid leukemogen. However, the mechanistic basis for this association is still debated.OBJECTIVES: We aimed to evaluate whether circulating immune/inflammation markers were altered in workers occupationally exposed to formaldehyde.METHODS: Using a multiplexed bead-based assay, we measured serum levels of 38 immune/inflammation markers in a cross-sectional study of 43 formaldehyde-exposed and 51 unexposed factory workers in Guangdong, China. Linear regression models adjusting for potential confounders were used to compare marker levels in exposed and unexposed workers.RESULTS: We found significantly lower circulating levels of two markers among exposed factory workers compared with unexposed controls that remained significant after adjusting for potential confounders and multiple comparisons using a false discovery rate of 10%, including chemokine (C-X-C motif) ligand 11 (36.2 pg/ml in exposed versus 48.4 pg/ml in controls, P = 0.0008) and thymus and activation regulated chemokine (52.7 pg/ml in exposed versus 75.0 pg/ml in controls, P = 0.0028), suggesting immunosuppression among formaldehyde-exposed workers.CONCLUSIONS: Our findings are consistent with recently emerging understanding that immunosuppression might be associated with myeloid diseases. These findings, if replicated in a larger study, may provide insights into the mechanisms by which formaldehyde promotes leukemogenesis.

U2 - 10.1093/carcin/bgv055

DO - 10.1093/carcin/bgv055

M3 - Article

C2 - 25908645

SN - 0143-3334

VL - 36

SP - 852

EP - 857

JO - Carcinogenesis

JF - Carcinogenesis

IS - 8

ER -

Circulating immune/inflammation markers in Chinese workers occupationally exposed to formaldehyde

Abstract

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