TY - JOUR
T1 - Childhood maltreatment mediates the effect of the genetic background on psychosis risk in young adults
AU - Marchi, Mattia
AU - Elkrief, Laurent
AU - Alkema, Anne
AU - van Gastel, Willemijn
AU - Schubart, Chris D.
AU - van Eijk, Kristel R
AU - Luykx, Jurjen J
AU - Branje, Susan
AU - Mastrotheodoros, Stefanos
AU - Galeazzi, Gian M.
AU - Van Os, Jim
AU - Cecil, Charlotte A.
AU - Boks, Marco P.
PY - 2022
Y1 - 2022
N2 - Childhood maltreatment (CM) and genetic vulnerability are both risk factors for psychosis, but the relations between them are not fully understood. Guided by the recent identification of genetic risk to CM, this study investigates the hypothesis that genetic risk to schizophrenia also increases the risk of CM and thus impacts psychosis risk. The relationship between schizophrenia polygenetic risk, CM, and psychotic-like experiences (PLE) was investigated in participants from the Utrecht Cannabis Cohort (N = 1262) and replicated in the independent IMAGEN cohort (N = 1740). Schizophrenia polygenic risk score (SZ-PRS) were calculated from the most recent GWAS. The relationship between CM, PRS, and PLE was first investigated using multivariate linear regression. Next, mediation of CM in the pathway linking SZ-PRS and PLE was examined by structural equation modeling, while adjusting for a set of potential mediators including cannabis use, smoking, and neuroticism. In agreement with previous studies, PLE were strongly associated with SZ-PRS (B = 0.190, p = 0.009) and CM (B = 0.575, p
AB - Childhood maltreatment (CM) and genetic vulnerability are both risk factors for psychosis, but the relations between them are not fully understood. Guided by the recent identification of genetic risk to CM, this study investigates the hypothesis that genetic risk to schizophrenia also increases the risk of CM and thus impacts psychosis risk. The relationship between schizophrenia polygenetic risk, CM, and psychotic-like experiences (PLE) was investigated in participants from the Utrecht Cannabis Cohort (N = 1262) and replicated in the independent IMAGEN cohort (N = 1740). Schizophrenia polygenic risk score (SZ-PRS) were calculated from the most recent GWAS. The relationship between CM, PRS, and PLE was first investigated using multivariate linear regression. Next, mediation of CM in the pathway linking SZ-PRS and PLE was examined by structural equation modeling, while adjusting for a set of potential mediators including cannabis use, smoking, and neuroticism. In agreement with previous studies, PLE were strongly associated with SZ-PRS (B = 0.190, p = 0.009) and CM (B = 0.575, p
U2 - 10.1038/s41398-022-01975-1
DO - 10.1038/s41398-022-01975-1
M3 - Article
SN - 2158-3188
VL - 12
SP - 1
EP - 10
JO - Translational Psychiatry
JF - Translational Psychiatry
M1 - 219
ER -