Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate

J.F.W. Nijsen; M.J. Van Steenbergen; H. Kooijman; H. Talsma; L.M.J. Kroon-Batenburg; M. Van De Weert; P.P. Van Rijk; A. De Witte; A.D. Van Het Schip; W.E. Hennink

doi:10.1016/S0142-9612(01)00055-2

Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate

J.F.W. Nijsen, M.J. Van Steenbergen, H. Kooijman, H. Talsma, L.M.J. Kroon-Batenburg, M. Van De Weert, P.P. Van Rijk, A. De Witte, A.D. Van Het Schip, W.E. Hennink

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Holmium-loaded PLLA microspheres are useful systems in radioembolization therapy of liver metastases because of their low density, biodegradability and favourable radiation characteristics. Neutron activated Ho-loaded microspheres showed a surprisingly low release of the relatively small holmium complex. In this paper factors responsible for this behaviour are investigated, in particular by the use of differential scanning calorimetry, scanning electron microscopy, infrared spectroscopy and X-ray diffraction. The holmium complex is soluble in PLLA up to 8% in films and 17% in microspheres. Interactions between carbonyl groups of PLLA, and the Ho-ion in the HoAcAc complex, explain very satisfactorily the high stability of holmium-loaded microspheres. Copyright © 2001 Elsevier Science Ltd.

Original language	English
Pages (from-to)	3073-3081
Number of pages	9
Journal	Biomaterials
Volume	22
Issue number	22
DOIs	https://doi.org/10.1016/S0142-9612(01)00055-2
Publication status	Published - 15 Nov 2001

Keywords

Acetylacetonate
Holmium
MDSC
Microspheres
PLLA
Radio therapy
holmium
holmium acetylacetonate
microsphere
polylactic acid
unclassified drug
aqueous solution
article
biodegradation
differential scanning calorimetry
drug delivery system
drug targeting
evaporation
liver metastasis
priority journal
scanning electron microscopy
X ray diffraction

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10.1016/S0142-9612(01)00055-2

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@article{38ab5e1ab50940088e92dadcf3470e69,

title = "Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate",

abstract = "Holmium-loaded PLLA microspheres are useful systems in radioembolization therapy of liver metastases because of their low density, biodegradability and favourable radiation characteristics. Neutron activated Ho-loaded microspheres showed a surprisingly low release of the relatively small holmium complex. In this paper factors responsible for this behaviour are investigated, in particular by the use of differential scanning calorimetry, scanning electron microscopy, infrared spectroscopy and X-ray diffraction. The holmium complex is soluble in PLLA up to 8% in films and 17% in microspheres. Interactions between carbonyl groups of PLLA, and the Ho-ion in the HoAcAc complex, explain very satisfactorily the high stability of holmium-loaded microspheres. Copyright {\textcopyright} 2001 Elsevier Science Ltd.",

keywords = "Acetylacetonate, Holmium, MDSC, Microspheres, PLLA, Radio therapy, holmium, holmium acetylacetonate, microsphere, polylactic acid, unclassified drug, aqueous solution, article, biodegradation, differential scanning calorimetry, drug delivery system, drug targeting, evaporation, liver metastasis, priority journal, scanning electron microscopy, X ray diffraction",

author = "J.F.W. Nijsen and {Van Steenbergen}, M.J. and H. Kooijman and H. Talsma and L.M.J. Kroon-Batenburg and {Van De Weert}, M. and {Van Rijk}, P.P. and {De Witte}, A. and {Van Het Schip}, A.D. and W.E. Hennink",

year = "2001",

month = nov,

day = "15",

doi = "10.1016/S0142-9612(01)00055-2",

language = "English",

volume = "22",

pages = "3073--3081",

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T1 - Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate

AU - Nijsen, J.F.W.

AU - Van Steenbergen, M.J.

AU - Kooijman, H.

AU - Talsma, H.

AU - Kroon-Batenburg, L.M.J.

AU - Van De Weert, M.

AU - Van Rijk, P.P.

AU - De Witte, A.

AU - Van Het Schip, A.D.

AU - Hennink, W.E.

PY - 2001/11/15

Y1 - 2001/11/15

N2 - Holmium-loaded PLLA microspheres are useful systems in radioembolization therapy of liver metastases because of their low density, biodegradability and favourable radiation characteristics. Neutron activated Ho-loaded microspheres showed a surprisingly low release of the relatively small holmium complex. In this paper factors responsible for this behaviour are investigated, in particular by the use of differential scanning calorimetry, scanning electron microscopy, infrared spectroscopy and X-ray diffraction. The holmium complex is soluble in PLLA up to 8% in films and 17% in microspheres. Interactions between carbonyl groups of PLLA, and the Ho-ion in the HoAcAc complex, explain very satisfactorily the high stability of holmium-loaded microspheres. Copyright © 2001 Elsevier Science Ltd.

AB - Holmium-loaded PLLA microspheres are useful systems in radioembolization therapy of liver metastases because of their low density, biodegradability and favourable radiation characteristics. Neutron activated Ho-loaded microspheres showed a surprisingly low release of the relatively small holmium complex. In this paper factors responsible for this behaviour are investigated, in particular by the use of differential scanning calorimetry, scanning electron microscopy, infrared spectroscopy and X-ray diffraction. The holmium complex is soluble in PLLA up to 8% in films and 17% in microspheres. Interactions between carbonyl groups of PLLA, and the Ho-ion in the HoAcAc complex, explain very satisfactorily the high stability of holmium-loaded microspheres. Copyright © 2001 Elsevier Science Ltd.

KW - Acetylacetonate

KW - Holmium

KW - MDSC

KW - Microspheres

KW - PLLA

KW - Radio therapy

KW - holmium

KW - holmium acetylacetonate

KW - microsphere

KW - polylactic acid

KW - unclassified drug

KW - aqueous solution

KW - article

KW - biodegradation

KW - differential scanning calorimetry

KW - drug delivery system

KW - drug targeting

KW - evaporation

KW - liver metastasis

KW - priority journal

KW - scanning electron microscopy

KW - X ray diffraction

U2 - 10.1016/S0142-9612(01)00055-2

DO - 10.1016/S0142-9612(01)00055-2

M3 - Article

SN - 0142-9612

VL - 22

SP - 3073

EP - 3081

JO - Biomaterials

JF - Biomaterials

IS - 22

ER -

Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate

Abstract

Keywords

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