Characteristics and diagnostic significance of spontaneous wheezing in children with asthma: Results of continuous in vivo sound recording

The characteristics and diagnostics of wheezing during induced airway obstruction are well documented. The present study addressed (a) the characteristics of spontaneous wheezing with respect to a possible distinction between wheezes during in vivo versus induced airway obstruction, and (b) the relationship between in vivo wheezing and fluctuations in peak expiratory flow (PEF). Tracheal sounds were continuously recorded from 50 children and adolescents with asthma and 10 without asthma in the home environment. Wheezes underwent a qualitative analysis, including their concomittant sound frequencies. Presence of wheezing was scored by two examiners independently and was related to PEF. Spontaneous wheeze varied from solitary rhonchi to prolonged rhythms of loud strider, and resembled the "induced" wheezes recorded previously. Power spectra showed that the spectral contents (frequency distribution) were comparable, although the in vivo patterns were more prolonged in duration. The diagnostic sensitivity and specificity of wheezing for a reduction in PEF of >20% were 88% and 92%, respectively. It was concluded that in vivo wheeze resembled induced wheeze and was a diagnostically reliable symptom with respect to asthma exacerbations.