Chapter 14: Population-based study designs in molecular epidemiology

M. García-Closas, R.C.H. Vermeulen, D. Cox, Q. Lan, N.E. Caporaso, N. Rothman

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

    Abstract

    This chapter will discuss design considerations for epidemiological studies that use biomarkers in the framework of etiologic investigations. The main focus will be on describing the incorporation of biomarkers into the main epidemiologic study designs, including cross-sectional or short-term longitudinal designs to characterize biomarkers, and prospective cohort and case-control studies to evaluate biomarker-disease associations. The advantages and limitations of each design will be presented, and the impact of study design on the feasibility of different approaches to exposure assessment and biospecimen collection and processing will be discussed.
    Original languageEnglish
    Title of host publicationMolecular Epidemiology: Pinciples and Practices
    EditorsN. Rothman, P. Hainaut, P. Schulte, M. Smith, P. Boffetta, F. Perera
    Place of PublicationGeneva, Switzerland
    PublisherWHO Press
    Pages241-259
    Number of pages19
    ISBN (Print)9789283221630
    Publication statusPublished - 2012

    Publication series

    NameIARC scientific publications
    Number163

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