TY - JOUR
T1 - Challenges in cybersecurity
T2 - Lessons from biological defense systems
AU - Schrom, Edward
AU - Kinzig, Ann
AU - Forrest, Stephanie
AU - Graham, Andrea L
AU - Levin, Simon A
AU - Bergstrom, Carl T
AU - Castillo-Chavez, Carlos
AU - Collins, James P
AU - de Boer, Rob J
AU - Doupé, Adam
AU - Ensafi, Roya
AU - Feldman, Stuart
AU - Grenfell, Bryan T
AU - Halderman, J Alex
AU - Huijben, Silvie
AU - Maley, Carlo
AU - Moses, Melanie
AU - Perelson, Alan S
AU - Perrings, Charles
AU - Plotkin, Joshua
AU - Rexford, Jennifer
AU - Tiwari, Mohit
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/8
Y1 - 2023/8
N2 - Defending against novel, repeated, or unpredictable attacks, while avoiding attacks on the 'self', are the central problems of both mammalian immune systems and computer systems. Both systems have been studied in great detail, but with little exchange of information across the different disciplines. Here, we present a conceptual framework for structured comparisons across the fields of biological immunity and cybersecurity, by framing the context of defense, considering different (combinations of) defensive strategies, and evaluating defensive performance. Throughout this paper, we pose open questions for further exploration. We hope to spark the interdisciplinary discovery of general principles of optimal defense, which can be understood and applied in biological immunity, cybersecurity, and other defensive realms.
AB - Defending against novel, repeated, or unpredictable attacks, while avoiding attacks on the 'self', are the central problems of both mammalian immune systems and computer systems. Both systems have been studied in great detail, but with little exchange of information across the different disciplines. Here, we present a conceptual framework for structured comparisons across the fields of biological immunity and cybersecurity, by framing the context of defense, considering different (combinations of) defensive strategies, and evaluating defensive performance. Throughout this paper, we pose open questions for further exploration. We hope to spark the interdisciplinary discovery of general principles of optimal defense, which can be understood and applied in biological immunity, cybersecurity, and other defensive realms.
KW - Complex systems
KW - Cybersecurity
KW - Defense
KW - Immunology
UR - http://www.scopus.com/inward/record.url?scp=85164294299&partnerID=8YFLogxK
U2 - 10.1016/j.mbs.2023.109024
DO - 10.1016/j.mbs.2023.109024
M3 - Article
C2 - 37270102
SN - 0025-5564
VL - 362
JO - Mathematical Biosciences
JF - Mathematical Biosciences
M1 - 109024
ER -