Cellular polyploidy in organ homeostasis and regeneration

Juntao Fang, Alain de Bruin, Andreas Villunger, Raymond Schiffelers, Zhiyong Lei*, Joost P G Sluijter*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Polyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals. Here, we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid. Moreover, we discuss its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.

Original languageEnglish
Pages (from-to)560-578
Number of pages19
JournalProtein and Cell
Issue number8
Early online date31 Dec 2022
Publication statusPublished - 1 Aug 2023


  • Humans
  • Liver
  • Hepatocytes
  • Cell Cycle
  • Polyploidy
  • Homeostasis


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