Cellular polyploidy in organ homeostasis and regeneration

Juntao Fang; Alain de Bruin; Andreas Villunger; Raymond Schiffelers; Zhiyong Lei; Joost P G Sluijter

doi:10.1093/procel/pwac064

Cellular polyploidy in organ homeostasis and regeneration

Juntao Fang, Alain de Bruin, Andreas Villunger, Raymond Schiffelers, Zhiyong Lei^*, Joost P G Sluijter^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Polyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals. Here, we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid. Moreover, we discuss its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.

Original language	English
Pages (from-to)	560-578
Number of pages	19
Journal	Protein and Cell
Volume	14
Issue number	8
Early online date	31 Dec 2022
DOIs	https://doi.org/10.1093/procel/pwac064
Publication status	Published - 1 Aug 2023

Bibliographical note

Publisher Copyright:
©The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.

Keywords

Humans
Liver
Hepatocytes
Cell Cycle
Polyploidy
Homeostasis

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pwac064Final published version, 854 KBLicence: CC BY

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AU - Schiffelers, Raymond

AU - Lei, Zhiyong

AU - Sluijter, Joost P G

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KW - Homeostasis

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Cellular polyploidy in organ homeostasis and regeneration

Abstract

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Keywords

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