Cellular logistics: Unraveling the interplay between microtubule organization and intracellular transport

Mithila Burute; Lukas C. Kapitein

doi:10.1146/annurev-cellbio-100818-125149

Cellular logistics: Unraveling the interplay between microtubule organization and intracellular transport

Research output: Contribution to journal › Review article › peer-review

Abstract

Microtubules are core components of the cytoskeleton and serve as tracks for motor protein-based intracellular transport. Microtubule networks are highly diverse across different cell types and are believed to adapt to cell type-specific transport demands. Here we review how the spatial organization of different subsets of microtubules into higher-order networks determines the traffic rules for motor-based transport in different animal cell types. We describe the interplay between microtubule network organization and motor-based transport within epithelial cells, oocytes, neurons, cilia, and the spindle apparatus.

Original language	English
Pages (from-to)	29-54
Number of pages	26
Journal	Annual Review of Cell and Developmental Biology
Volume	35
DOIs	https://doi.org/10.1146/annurev-cellbio-100818-125149
Publication status	Published - 1 Jan 2019

Funding

We are grateful to Wilco Nijenhuis and Anna Akhmanova for feedback. M.B. and L.C.K. are supported by an EMBO fellowship and an ERC Consolidator grant (819219), respectively.

Keywords

cytoskeleton
intracellular transport
microtubules
motor proteins
polarity
posttranslational modifications

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10.1146/annurev-cellbio-100818-125149

buruteFinal published version, 1.99 MBLicence: Taverne

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Cellular logistics: Unraveling the interplay between microtubule organization and intracellular transport

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Keywords

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