Cell sources proposed for nucleus pulposus regeneration

Rebecca J. Williams; Marianna A. Tryfonidou; Joseph Wiliam Snuggs; Christine Lyn Le Maitre

doi:10.1002/jsp2.1175

Cell sources proposed for nucleus pulposus regeneration

Rebecca J. Williams, Marianna A. Tryfonidou, Joseph Wiliam Snuggs, Christine Lyn Le Maitre^*

^*Corresponding author for this work

Sheffield Hallam University

Research output: Contribution to journal › Review article › peer-review

Abstract

Lower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration of the intervertebral disc (IVD). The current treatments for chronic back pain only provide alleviation of symptoms through pain relief, tissue removal, or spinal fusion; none of which target regenerating the degenerate IVD. As nucleus pulposus (NP) degeneration is thought to represent a key initiation site of IVD degeneration, cell therapy that specifically targets the restoration of the NP has been reviewed here. A literature search to quantitatively assess all cell types used in NP regeneration was undertaken. With key cell sources: NP cells; annulus fibrosus cells; notochordal cells; chondrocytes; bone marrow mesenchymal stromal cells; adipose-derived stromal cells; and induced pluripotent stem cells extensively analyzed for their regenerative potential of the NP. This review highlights: accessibility; expansion capability in vitro; cell survival in an IVD environment; regenerative potential; and safety for these key potential cell sources. In conclusion, while several potential cell sources have been proposed, iPSC may provide the most promising regenerative potential.

Original language	English
Article number	e1175
Pages (from-to)	1-27
Journal	JOR Spine
Volume	4
Issue number	4
Early online date	24 Nov 2021
DOIs	https://doi.org/10.1002/jsp2.1175
Publication status	Published - Dec 2021

Keywords

biologic therapies
regenerative medicine
stem cell
tissue engineering

Access to Document

10.1002/jsp2.1175Licence: CC BY-NC-ND

JOR Spine - 2021 - Williams - Cell sources proposed for nucleus pulposus regenerationFinal published version, 6.85 MBLicence: CC BY-NC-ND

Cite this

@article{3ef8cbb9d4554970a1d03b5de3edeaa6,

title = "Cell sources proposed for nucleus pulposus regeneration",

abstract = "Lower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration of the intervertebral disc (IVD). The current treatments for chronic back pain only provide alleviation of symptoms through pain relief, tissue removal, or spinal fusion; none of which target regenerating the degenerate IVD. As nucleus pulposus (NP) degeneration is thought to represent a key initiation site of IVD degeneration, cell therapy that specifically targets the restoration of the NP has been reviewed here. A literature search to quantitatively assess all cell types used in NP regeneration was undertaken. With key cell sources: NP cells; annulus fibrosus cells; notochordal cells; chondrocytes; bone marrow mesenchymal stromal cells; adipose-derived stromal cells; and induced pluripotent stem cells extensively analyzed for their regenerative potential of the NP. This review highlights: accessibility; expansion capability in vitro; cell survival in an IVD environment; regenerative potential; and safety for these key potential cell sources. In conclusion, while several potential cell sources have been proposed, iPSC may provide the most promising regenerative potential.",

keywords = "biologic therapies, regenerative medicine, stem cell, tissue engineering",

author = "Williams, {Rebecca J.} and Tryfonidou, {Marianna A.} and Snuggs, {Joseph Wiliam} and {Le Maitre}, {Christine Lyn}",

note = "Funding Information: The authors would like to acknowledge the following sources of support for this manuscript: European Union's Horizon 2020 research 52 and innovation program iPSpine under the grant agreement #825925 ( www.ipspine.eu ); MT acknowledges the financial support by the Dutch Arthritis Society (LLP22). Publisher Copyright: {\textcopyright} 2021 The Authors. JOR Spine published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.",

year = "2021",

month = dec,

doi = "10.1002/jsp2.1175",

language = "English",

volume = "4",

pages = "1--27",

journal = "JOR Spine",

issn = "2572-1143",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "4",

}

TY - JOUR

T1 - Cell sources proposed for nucleus pulposus regeneration

AU - Williams, Rebecca J.

AU - Tryfonidou, Marianna A.

AU - Snuggs, Joseph Wiliam

AU - Le Maitre, Christine Lyn

N1 - Funding Information: The authors would like to acknowledge the following sources of support for this manuscript: European Union's Horizon 2020 research 52 and innovation program iPSpine under the grant agreement #825925 ( www.ipspine.eu ); MT acknowledges the financial support by the Dutch Arthritis Society (LLP22). Publisher Copyright: © 2021 The Authors. JOR Spine published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.

PY - 2021/12

Y1 - 2021/12

N2 - Lower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration of the intervertebral disc (IVD). The current treatments for chronic back pain only provide alleviation of symptoms through pain relief, tissue removal, or spinal fusion; none of which target regenerating the degenerate IVD. As nucleus pulposus (NP) degeneration is thought to represent a key initiation site of IVD degeneration, cell therapy that specifically targets the restoration of the NP has been reviewed here. A literature search to quantitatively assess all cell types used in NP regeneration was undertaken. With key cell sources: NP cells; annulus fibrosus cells; notochordal cells; chondrocytes; bone marrow mesenchymal stromal cells; adipose-derived stromal cells; and induced pluripotent stem cells extensively analyzed for their regenerative potential of the NP. This review highlights: accessibility; expansion capability in vitro; cell survival in an IVD environment; regenerative potential; and safety for these key potential cell sources. In conclusion, while several potential cell sources have been proposed, iPSC may provide the most promising regenerative potential.

AB - Lower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration of the intervertebral disc (IVD). The current treatments for chronic back pain only provide alleviation of symptoms through pain relief, tissue removal, or spinal fusion; none of which target regenerating the degenerate IVD. As nucleus pulposus (NP) degeneration is thought to represent a key initiation site of IVD degeneration, cell therapy that specifically targets the restoration of the NP has been reviewed here. A literature search to quantitatively assess all cell types used in NP regeneration was undertaken. With key cell sources: NP cells; annulus fibrosus cells; notochordal cells; chondrocytes; bone marrow mesenchymal stromal cells; adipose-derived stromal cells; and induced pluripotent stem cells extensively analyzed for their regenerative potential of the NP. This review highlights: accessibility; expansion capability in vitro; cell survival in an IVD environment; regenerative potential; and safety for these key potential cell sources. In conclusion, while several potential cell sources have been proposed, iPSC may provide the most promising regenerative potential.

KW - biologic therapies

KW - regenerative medicine

KW - stem cell

KW - tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=85120646397&partnerID=8YFLogxK

U2 - 10.1002/jsp2.1175

DO - 10.1002/jsp2.1175

M3 - Review article

C2 - 35005441

SN - 2572-1143

VL - 4

SP - 1

EP - 27

JO - JOR Spine

JF - JOR Spine

IS - 4

M1 - e1175

ER -

Cell sources proposed for nucleus pulposus regeneration

Abstract

Keywords

Access to Document

Fingerprint

Cite this