Cell competition in primary and metastatic colorectal cancer

Merel Elise van Luyk; Ana Krotenberg Garcia; Maria Lamprou; Saskia Jacoba Elisabeth Suijkerbuijk

doi:10.1038/s41389-024-00530-5

Cell competition in primary and metastatic colorectal cancer

Merel Elise van Luyk
, Ana Krotenberg Garcia
, Maria Lamprou
, Saskia Jacoba Elisabeth Suijkerbuijk^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Adult tissues set the scene for a continuous battle between cells, where a comparison of cellular fitness results in the elimination of weaker "loser" cells. This phenomenon, named cell competition, is beneficial for tissue integrity and homeostasis. In fact, cell competition plays a crucial role in tumor suppression, through elimination of early malignant cells, as part of Epithelial Defense Against Cancer. However, it is increasingly apparent that cell competition doubles as a tumor-promoting mechanism. The comparative nature of cell competition means that mutational background, proliferation rate and polarity all factor in to determine the outcome of these processes. In this review, we explore the intricate and context-dependent involvement of cell competition in homeostasis and regeneration, as well as during initiation and progression of primary and metastasized colorectal cancer. We provide a comprehensive overview of molecular and cellular mechanisms governing cell competition and its parallels with regeneration.

Original language	English
Article number	28
Pages (from-to)	1-18
Number of pages	19
Journal	Oncogenesis
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41389-024-00530-5
Publication status	Published - 26 Jul 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

Funding

This work was financially supported by Dutch Cancer Society Young Investigator Grant 11491 / 2018-1 and (to SJES). This publication is part of the project \u201CCommunication of cellular fitness in intestinal organoids\u201D (with project number OCENW.M.22.032 of the research programme Open Competition Domain Science M1 which is (partly) financed by the Dutch Research Council (NWO).

Funders	Funder number
NWO
Dutch Research Council
Dutch Cancer Society	OCENW.M.22.032, 11491 / 2018-1

Keywords

Beta-catenin
Clonal evolution
Eph receptors
Hippo signaling-pathway
Intestinal regeneration
Liver stem-cells
Paneth cells
Partial-hepatectomy
Progenitor cells
Ulcerative-colitis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41389-024-00530-5Licence: CC BY

s41389-024-00530-5Final published version, 2.65 MBLicence: CC BY

Cite this

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title = "Cell competition in primary and metastatic colorectal cancer",

abstract = "Adult tissues set the scene for a continuous battle between cells, where a comparison of cellular fitness results in the elimination of weaker {"}loser{"} cells. This phenomenon, named cell competition, is beneficial for tissue integrity and homeostasis. In fact, cell competition plays a crucial role in tumor suppression, through elimination of early malignant cells, as part of Epithelial Defense Against Cancer. However, it is increasingly apparent that cell competition doubles as a tumor-promoting mechanism. The comparative nature of cell competition means that mutational background, proliferation rate and polarity all factor in to determine the outcome of these processes. In this review, we explore the intricate and context-dependent involvement of cell competition in homeostasis and regeneration, as well as during initiation and progression of primary and metastasized colorectal cancer. We provide a comprehensive overview of molecular and cellular mechanisms governing cell competition and its parallels with regeneration.",

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doi = "10.1038/s41389-024-00530-5",

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T1 - Cell competition in primary and metastatic colorectal cancer

AU - van Luyk, Merel Elise

AU - Garcia, Ana Krotenberg

AU - Lamprou, Maria

AU - Suijkerbuijk, Saskia Jacoba Elisabeth

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/7/26

Y1 - 2024/7/26

N2 - Adult tissues set the scene for a continuous battle between cells, where a comparison of cellular fitness results in the elimination of weaker "loser" cells. This phenomenon, named cell competition, is beneficial for tissue integrity and homeostasis. In fact, cell competition plays a crucial role in tumor suppression, through elimination of early malignant cells, as part of Epithelial Defense Against Cancer. However, it is increasingly apparent that cell competition doubles as a tumor-promoting mechanism. The comparative nature of cell competition means that mutational background, proliferation rate and polarity all factor in to determine the outcome of these processes. In this review, we explore the intricate and context-dependent involvement of cell competition in homeostasis and regeneration, as well as during initiation and progression of primary and metastasized colorectal cancer. We provide a comprehensive overview of molecular and cellular mechanisms governing cell competition and its parallels with regeneration.

AB - Adult tissues set the scene for a continuous battle between cells, where a comparison of cellular fitness results in the elimination of weaker "loser" cells. This phenomenon, named cell competition, is beneficial for tissue integrity and homeostasis. In fact, cell competition plays a crucial role in tumor suppression, through elimination of early malignant cells, as part of Epithelial Defense Against Cancer. However, it is increasingly apparent that cell competition doubles as a tumor-promoting mechanism. The comparative nature of cell competition means that mutational background, proliferation rate and polarity all factor in to determine the outcome of these processes. In this review, we explore the intricate and context-dependent involvement of cell competition in homeostasis and regeneration, as well as during initiation and progression of primary and metastasized colorectal cancer. We provide a comprehensive overview of molecular and cellular mechanisms governing cell competition and its parallels with regeneration.

KW - Beta-catenin

KW - Clonal evolution

KW - Eph receptors

KW - Hippo signaling-pathway

KW - Intestinal regeneration

KW - Liver stem-cells

KW - Paneth cells

KW - Partial-hepatectomy

KW - Progenitor cells

KW - Ulcerative-colitis

UR - https://www.scopus.com/pages/publications/85199884584

U2 - 10.1038/s41389-024-00530-5

DO - 10.1038/s41389-024-00530-5

M3 - Review article

C2 - 39060237

SN - 2157-9024

VL - 13

SP - 1

EP - 18

JO - Oncogenesis

JF - Oncogenesis

IS - 1

M1 - 28

ER -

Cell competition in primary and metastatic colorectal cancer

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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Cite this