Cardiac troponins as indicators of acute myocardial damage in dogs

Iwan A Burgener, Alan Kovacevic, G Neal Mauldin, Christophe W Lombard

    Research output: Contribution to journalArticleAcademicpeer-review


    Cardiac troponin I (cTnI) and T (cTnT) have a high sequence homology across phyla and are sensitive and specific markers of myocardial damage. The purpose of this study was to evaluate the Cardiac Reader, a human point-of-care system for the determination of cTnT and myoglobin, and the Abbott Axsym System for the determination of cTnI and creatine kinase isoenzyme MB (CK-MB) in healthy dogs and in dogs at risk for acute myocardial damage because of gastric dilatation-volvulus (GDV) and blunt chest trauma (BCT). In healthy dogs (n = 56), cTnI was below detection limits (<0.1 microg/L) in 35 of 56 dogs (reference range 0-0.7 microg/L), and cTnT was not measurable (<0.05 ng/mL) in all but 1 dog. At presentation, cTnI, CK-MB, myoglobin, and lactic acid were all significantly higher in dogs with GDV (n = 28) and BCT (n = 8) than in control dogs (P < .001), but cTnT was significantly higher only in dogs with BCT (P = .033). Increased cTnI or cTnT values were found in 26 of 28 (highest values 1.1-369 microg/L) and 16 of 28 dogs (0.1-1.7 ng/mL) with GDV, and in 6 of 8 (2.3-82.4 microg/L) and 3 of 8 dogs (0.1-0.29 ng/mL) with BCT, respectively. In dogs suffering from GDV, cTnI and cTnT increased further within the first 48 hours (P < .001). Increased cardiac troponins suggestive of myocardial damage occurred in 93% of dogs with GDV and 75% with BCT. cTnI appeared more sensitive, but cTnT may be a negative prognostic indicator in GDV. Both systems tested seemed applicable for the measurement of canine cardiac troponins, with the Cardiac Reader particularly suitable for use in emergency settings.

    Original languageEnglish
    Pages (from-to)277-83
    Number of pages7
    JournalJournal of Veterinary Internal Medicine
    Issue number2
    Publication statusPublished - 6 Apr 2006


    • Animals
    • Biological Markers
    • Dog Diseases
    • Dogs
    • Female
    • Gastric Dilatation
    • Heart Diseases
    • Male
    • Myoglobin
    • Point-of-Care Systems
    • Reagent Kits, Diagnostic
    • Risk Factors
    • Stomach Volvulus
    • Troponin C
    • Troponin I
    • Wounds, Nonpenetrating


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