Cannabinoid receptor-2 expression in canine multicentric diffuse large B-cell lymphoma: An immunohistochemical, digital pathology and clinical analysis

Valentina Rinaldi; Lorenzo Ressel; Laura Bongiovanni; Paolo Emidio Crisi; Andrea Boari; David Killick; Roberto Chiocchetti; Riccardo Finotello

doi:10.1016/j.rvsc.2024.105411

Cannabinoid receptor-2 expression in canine multicentric diffuse large B-cell lymphoma: An immunohistochemical, digital pathology and clinical analysis

Valentina Rinaldi^*, Lorenzo Ressel, Laura Bongiovanni, Paolo Emidio Crisi, Andrea Boari, David Killick, Roberto Chiocchetti, Riccardo Finotello

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The cannabinoid 2 receptor (CB2R) is a crucial element of the endocannabinoid system (ECS), which is predominantly expressed on cells of the reticuloendothelial system. Alterations in CB2R expression have shown a prognostic role in various human neoplastic diseases and its expression has been studied in canine mast cell tumours (MCT). Canine diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in dogs and has a variable clinical behaviour. Expression of CB2R was assessed by means of immunohistochemistry in fifteen dogs with proven histological diagnosis of DLBCL. A semiquantitative and quantitative assessment of immunoreactivity (IR) by digital analysis was performed in all cases. Our results indicate that CB2R expression is conserved in canine DLBCL but does not correlate with clinical outcome.

Original language	English
Article number	105411
Number of pages	6
Journal	Research in Veterinary Science
Volume	180
Early online date	13 Sept 2024
DOIs	https://doi.org/10.1016/j.rvsc.2024.105411
Publication status	Published - Nov 2024

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Ltd

Keywords

CB2R
Digital pathology
Dog
Histopathology
Lymphoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.rvsc.2024.105411

1-s2.0-S0034528824002789-mainFinal published version, 3.59 MBLicence: Taverne

Cite this

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title = "Cannabinoid receptor-2 expression in canine multicentric diffuse large B-cell lymphoma: An immunohistochemical, digital pathology and clinical analysis",

abstract = "The cannabinoid 2 receptor (CB2R) is a crucial element of the endocannabinoid system (ECS), which is predominantly expressed on cells of the reticuloendothelial system. Alterations in CB2R expression have shown a prognostic role in various human neoplastic diseases and its expression has been studied in canine mast cell tumours (MCT). Canine diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in dogs and has a variable clinical behaviour. Expression of CB2R was assessed by means of immunohistochemistry in fifteen dogs with proven histological diagnosis of DLBCL. A semiquantitative and quantitative assessment of immunoreactivity (IR) by digital analysis was performed in all cases. Our results indicate that CB2R expression is conserved in canine DLBCL but does not correlate with clinical outcome.",

keywords = "CB2R, Digital pathology, Dog, Histopathology, Lymphoma",

author = "Valentina Rinaldi and Lorenzo Ressel and Laura Bongiovanni and Crisi, {Paolo Emidio} and Andrea Boari and David Killick and Roberto Chiocchetti and Riccardo Finotello",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = nov,

doi = "10.1016/j.rvsc.2024.105411",

language = "English",

volume = "180",

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T1 - Cannabinoid receptor-2 expression in canine multicentric diffuse large B-cell lymphoma

T2 - An immunohistochemical, digital pathology and clinical analysis

AU - Rinaldi, Valentina

AU - Ressel, Lorenzo

AU - Bongiovanni, Laura

AU - Crisi, Paolo Emidio

AU - Boari, Andrea

AU - Killick, David

AU - Chiocchetti, Roberto

AU - Finotello, Riccardo

PY - 2024/11

Y1 - 2024/11

N2 - The cannabinoid 2 receptor (CB2R) is a crucial element of the endocannabinoid system (ECS), which is predominantly expressed on cells of the reticuloendothelial system. Alterations in CB2R expression have shown a prognostic role in various human neoplastic diseases and its expression has been studied in canine mast cell tumours (MCT). Canine diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in dogs and has a variable clinical behaviour. Expression of CB2R was assessed by means of immunohistochemistry in fifteen dogs with proven histological diagnosis of DLBCL. A semiquantitative and quantitative assessment of immunoreactivity (IR) by digital analysis was performed in all cases. Our results indicate that CB2R expression is conserved in canine DLBCL but does not correlate with clinical outcome.

AB - The cannabinoid 2 receptor (CB2R) is a crucial element of the endocannabinoid system (ECS), which is predominantly expressed on cells of the reticuloendothelial system. Alterations in CB2R expression have shown a prognostic role in various human neoplastic diseases and its expression has been studied in canine mast cell tumours (MCT). Canine diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in dogs and has a variable clinical behaviour. Expression of CB2R was assessed by means of immunohistochemistry in fifteen dogs with proven histological diagnosis of DLBCL. A semiquantitative and quantitative assessment of immunoreactivity (IR) by digital analysis was performed in all cases. Our results indicate that CB2R expression is conserved in canine DLBCL but does not correlate with clinical outcome.

KW - CB2R

KW - Digital pathology

KW - Dog

KW - Histopathology

KW - Lymphoma

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U2 - 10.1016/j.rvsc.2024.105411

DO - 10.1016/j.rvsc.2024.105411

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SN - 0034-5288

VL - 180

JO - Research in Veterinary Science

JF - Research in Veterinary Science

M1 - 105411

ER -

Cannabinoid receptor-2 expression in canine multicentric diffuse large B-cell lymphoma: An immunohistochemical, digital pathology and clinical analysis

Abstract

Bibliographical note

Keywords

UN SDGs

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