Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019

Global Burden of Disease 2019 Cancer Collaboration

doi:10.1001/jamaoncol.2021.6987

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019

Global Burden of Disease 2019 Cancer Collaboration

IRAS OH Epidemiology Chemical Agents

Eastern Washington University
University of Massachusetts Boston
Pathology and Laboratory Medicine Institute
Shahid Beheshti University of Medical Sciences
Tehran University of Medical Sciences
Tanta University
Jahrom University of Medical Sciences
University of Southern California
Yasouj University
Pediatric Allergy and Pulmonology Unit at Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Olabisi Onabanjo University
Karya Husada Institute of Health Sciences
Terasaki Institute for Biomedical Innovation
University of Management and Technology
Qom University of Medical Sciences
University of Technology Sydney
Foundation University Islamabad
Southeast Missouri State University
Shahrekord University of Medical Sciences
University of Kurdistan Hewler
Sulaimani Polytechnic University
St Paul's Hospital Millennium Medical College
Arba Minch University
Management and Science University, Malaysia
Philadelphia Department of Public Health
Geriatric and Long-Term Care Department
Mayo Evidence-Based Practice Center
Washington University St. Louis
Sultan Qaboos University
Iran University of Medical Sciences
Kuwait University
Department of Internal Medicine, Máxima Medical Centre Eindhoven, Eindhoven, The Netherlands; Department of Internal Medicine, Division of General Internal Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands; Department of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Arak University of Medical Sciences
Al-Zaytoonah University of Jordan
Qatar University
Alfaisal University
University of São Paulo School of Medicine
Research Group in Hospital Management and Health Policies
Muhimbili University of Health and Allied Sciences

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden.

Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019.

Evidence Review: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs).

Findings: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles.

Conclusions and Relevance: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.

Original language	English
Pages (from-to)	420-444
Journal	JAMA Oncology
Volume	8
Issue number	3
Early online date	30 Dec 2021
DOIs	https://doi.org/10.1001/jamaoncol.2021.6987
Publication status	Published - 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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@article{2f9eb90aa4a647aba81631a554764d0c,

title = "Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019",

abstract = "Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden.Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019.Evidence Review: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95\% uncertainty intervals (UIs).Findings: In 2019, there were an estimated 23.6 million (95\% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95\% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3\% (95\% UI, 20.3\%-32.3\%) increase in new cases, a 20.9\% (95\% UI, 14.2\%-27.6\%) increase in deaths, and a 16.0\% (95\% UI, 9.3\%-22.8\%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4\% (1.1\%-1.8\%) in the low SDI quintile to 5.7\% (4.2\%-7.1\%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles.Conclusions and Relevance: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.",

author = "\{Global Burden of Disease 2019 Cancer Collaboration\} and Kocarnik, \{Jonathan M\} and Kelly Compton and Dean, \{Frances E\} and Weijia Fu and Gaw, \{Brian L\} and Harvey, \{James D\} and Henrikson, \{Hannah Jacqueline\} and Dan Lu and Alyssa Pennini and Rixing Xu and Emad Ababneh and Mohsen Abbasi-Kangevari and Hedayat Abbastabar and Abd-Elsalam, \{Sherief M\} and Amir Abdoli and Aidin Abedi and Hassan Abidi and Hassan Abolhassani and Adedeji, \{Isaac Akinkunmi\} and Adnani, \{Qorinah Estiningtyas Sakilah\} and Advani, \{Shailesh M\} and Afzal, \{Muhammad Sohail\} and Mohammad Aghaali and Ahinkorah, \{Bright Opoku\} and Sajjad Ahmad and Tauseef Ahmad and Ali Ahmadi and Sepideh Ahmadi and \{Ahmed Rashid\}, Tarik and \{Ahmed Salih\}, Yusra and Akalu, \{Gizachew Taddesse\} and Addis Aklilu and Tayyaba Akram and Akunna, \{Chisom Joyqueenet\} and \{Al Hamad\}, Hanadi and Fares Alahdab and Ziyad Al-Aly and Saqib Ali and Yousef Alimohamadi and Vahid Alipour and Aljunid, \{Syed Mohamed\} and Motasem Alkhayyat and Amir Almasi-Hashiani and Almasri, \{Nihad A\} and Al-Maweri, \{Sadeq Ali Ali\} and Sami Almustanyir and Nivaldo Alonso and Nelson Alvis-Guzman and Hubert Amu and Eugenio Traini",

year = "2022",

doi = "10.1001/jamaoncol.2021.6987",

language = "English",

volume = "8",

pages = "420--444",

journal = "JAMA Oncology",

issn = "2374-2437",

publisher = "American Medical Association",

number = "3",

}

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019. / Global Burden of Disease 2019 Cancer Collaboration.
In: JAMA Oncology, Vol. 8, No. 3, 2022, p. 420-444.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019

T2 - A Systematic Analysis for the Global Burden of Disease Study 2019

AU - Global Burden of Disease 2019 Cancer Collaboration

AU - Kocarnik, Jonathan M

AU - Compton, Kelly

AU - Dean, Frances E

AU - Fu, Weijia

AU - Gaw, Brian L

AU - Harvey, James D

AU - Henrikson, Hannah Jacqueline

AU - Lu, Dan

AU - Pennini, Alyssa

AU - Xu, Rixing

AU - Ababneh, Emad

AU - Abbasi-Kangevari, Mohsen

AU - Abbastabar, Hedayat

AU - Abd-Elsalam, Sherief M

AU - Abdoli, Amir

AU - Abedi, Aidin

AU - Abidi, Hassan

AU - Abolhassani, Hassan

AU - Adedeji, Isaac Akinkunmi

AU - Adnani, Qorinah Estiningtyas Sakilah

AU - Advani, Shailesh M

AU - Afzal, Muhammad Sohail

AU - Aghaali, Mohammad

AU - Ahinkorah, Bright Opoku

AU - Ahmad, Sajjad

AU - Ahmad, Tauseef

AU - Ahmadi, Ali

AU - Ahmadi, Sepideh

AU - Ahmed Rashid, Tarik

AU - Ahmed Salih, Yusra

AU - Akalu, Gizachew Taddesse

AU - Aklilu, Addis

AU - Akram, Tayyaba

AU - Akunna, Chisom Joyqueenet

AU - Al Hamad, Hanadi

AU - Alahdab, Fares

AU - Al-Aly, Ziyad

AU - Ali, Saqib

AU - Alimohamadi, Yousef

AU - Alipour, Vahid

AU - Aljunid, Syed Mohamed

AU - Alkhayyat, Motasem

AU - Almasi-Hashiani, Amir

AU - Almasri, Nihad A

AU - Al-Maweri, Sadeq Ali Ali

AU - Almustanyir, Sami

AU - Alonso, Nivaldo

AU - Alvis-Guzman, Nelson

AU - Amu, Hubert

AU - Traini, Eugenio

PY - 2022

Y1 - 2022

N2 - Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden.Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019.Evidence Review: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs).Findings: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles.Conclusions and Relevance: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.

AB - Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden.Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019.Evidence Review: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs).Findings: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles.Conclusions and Relevance: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.

U2 - 10.1001/jamaoncol.2021.6987

DO - 10.1001/jamaoncol.2021.6987

M3 - Article

C2 - 34967848

SN - 2374-2437

VL - 8

SP - 420

EP - 444

JO - JAMA Oncology

JF - JAMA Oncology

IS - 3

ER -