Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

Aristotelis Chatziioannou; Panagiotis Georgiadis; Dennie G Hebels; Irene Liampa; Ioannis Valavanis; Ingvar A Bergdahl; Anders Johansson; Domenico Palli; Marc Chadeau-Hyam; Alexandros P. Siskos; Hector Keun; Maria Botsivali; Theo M C M de Kok; Almudena Espín Pérez; Jos C S Kleinjans; Paolo Vineis; Soterios A Kyrtopoulos; Ralph Gottschalk; Danitsja Van Leeuwen; Leen Timmermans; Benedetta Bendinelli; Rachel S. Kelly; Roel Vermeulen; Lutzen Portengen; Fatemeh Saberi-Hosnijeh; Beatrice Melin; Goran Hallmans; Per Lenner; Toby J. Athersuch; Manolis Kogevinas; Euripides G. Stephanou; Antonis Myridakis; Lucia Fazzo; Marco De Santis; Pietro Comba; Hannu Kiviranta; Panu Rantakokko; Riikka Airaksinen; Paivi Ruokojarvi; Mark Gilthorpe; Sarah Fleming; Thomas D Fleming; Yu Kang Tu; Bo A. G. Jonsson; Thomas Lundh; Wei J. Chen; Wen Chung Lee; Chuhsing Kate Hsiao; Kuo Liong Chien; Po Hsiu Kuo; Hung Hung; Shu Fen Liao

doi:10.1038/srep42870

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

Aristotelis Chatziioannou, Panagiotis Georgiadis, Dennie G Hebels, Irene Liampa, Ioannis Valavanis, Ingvar A Bergdahl, Anders Johansson, Domenico Palli, Marc Chadeau-Hyam, Alexandros P. Siskos, Hector Keun, Maria Botsivali, Theo M C M de Kok, Almudena Espín Pérez, Jos C S Kleinjans, Paolo Vineis, Soterios A Kyrtopoulos, Ralph Gottschalk, Danitsja Van Leeuwen, Leen TimmermansBenedetta Bendinelli, Rachel S. Kelly, Roel Vermeulen, Lutzen Portengen, Fatemeh Saberi-Hosnijeh, Beatrice Melin, Goran Hallmans, Per Lenner, Toby J. Athersuch, Manolis Kogevinas, Euripides G. Stephanou, Antonis Myridakis, Lucia Fazzo, Marco De Santis, Pietro Comba, Hannu Kiviranta, Panu Rantakokko, Riikka Airaksinen, Paivi Ruokojarvi, Mark Gilthorpe, Sarah Fleming, Thomas D Fleming, Yu Kang Tu, Bo A. G. Jonsson, Thomas Lundh, Wei J. Chen, Wen Chung Lee, Chuhsing Kate Hsiao, Kuo Liong Chien, Po Hsiu Kuo, Hung Hung, Shu Fen Liao

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 haem oxygenase 1) and BCL2L1 (BCL2- like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.

Original language	English
Article number	42870
Journal	Scientific Reports
Volume	7
DOIs	https://doi.org/10.1038/srep42870
Publication status	Published - 22 Feb 2017

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Chatziioannou, A., Georgiadis, P., Hebels, D. G., Liampa, I., Valavanis, I., Bergdahl, I. A., Johansson, A., Palli, D., Chadeau-Hyam, M., Siskos, A. P., Keun, H., Botsivali, M., de Kok, T. M. C. M., Pérez, A. E., Kleinjans, J. C. S., Vineis, P., Kyrtopoulos, S. A., Gottschalk, R., Van Leeuwen, D., ... Liao, S. F. (2017). Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases. Scientific Reports, 7, Article 42870. https://doi.org/10.1038/srep42870

@article{52236a067f204193b84ee9af921e1f61,

title = "Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases",

abstract = "We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 haem oxygenase 1) and BCL2L1 (BCL2- like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.",

author = "Aristotelis Chatziioannou and Panagiotis Georgiadis and Hebels, {Dennie G} and Irene Liampa and Ioannis Valavanis and Bergdahl, {Ingvar A} and Anders Johansson and Domenico Palli and Marc Chadeau-Hyam and Siskos, {Alexandros P.} and Hector Keun and Maria Botsivali and {de Kok}, {Theo M C M} and P{\'e}rez, {Almudena Esp{\'i}n} and Kleinjans, {Jos C S} and Paolo Vineis and Kyrtopoulos, {Soterios A} and Ralph Gottschalk and {Van Leeuwen}, Danitsja and Leen Timmermans and Benedetta Bendinelli and Kelly, {Rachel S.} and Roel Vermeulen and Lutzen Portengen and Fatemeh Saberi-Hosnijeh and Beatrice Melin and Goran Hallmans and Per Lenner and Athersuch, {Toby J.} and Manolis Kogevinas and Stephanou, {Euripides G.} and Antonis Myridakis and Lucia Fazzo and {De Santis}, Marco and Pietro Comba and Hannu Kiviranta and Panu Rantakokko and Riikka Airaksinen and Paivi Ruokojarvi and Mark Gilthorpe and Sarah Fleming and Fleming, {Thomas D} and Tu, {Yu Kang} and Jonsson, {Bo A. G.} and Thomas Lundh and Chen, {Wei J.} and Lee, {Wen Chung} and Hsiao, {Chuhsing Kate} and Chien, {Kuo Liong} and Kuo, {Po Hsiu} and Hung Hung and Liao, {Shu Fen}",

year = "2017",

month = feb,

day = "22",

doi = "10.1038/srep42870",

language = "English",

volume = "7",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

Chatziioannou, A, Georgiadis, P, Hebels, DG, Liampa, I, Valavanis, I, Bergdahl, IA, Johansson, A, Palli, D, Chadeau-Hyam, M, Siskos, AP, Keun, H, Botsivali, M, de Kok, TMCM, Pérez, AE, Kleinjans, JCS, Vineis, P, Kyrtopoulos, SA, Gottschalk, R, Van Leeuwen, D, Timmermans, L, Bendinelli, B, Kelly, RS, Vermeulen, R , Portengen, L , Saberi-Hosnijeh, F, Melin, B, Hallmans, G, Lenner, P, Athersuch, TJ, Kogevinas, M, Stephanou, EG, Myridakis, A, Fazzo, L, De Santis, M, Comba, P, Kiviranta, H, Rantakokko, P, Airaksinen, R, Ruokojarvi, P, Gilthorpe, M, Fleming, S, Fleming, TD, Tu, YK, Jonsson, BAG, Lundh, T, Chen, WJ, Lee, WC, Hsiao, CK, Chien, KL, Kuo, PH, Hung, H & Liao, SF 2017, 'Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases', Scientific Reports, vol. 7, 42870. https://doi.org/10.1038/srep42870

TY - JOUR

T1 - Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

AU - Chatziioannou, Aristotelis

AU - Georgiadis, Panagiotis

AU - Hebels, Dennie G

AU - Liampa, Irene

AU - Valavanis, Ioannis

AU - Bergdahl, Ingvar A

AU - Johansson, Anders

AU - Palli, Domenico

AU - Chadeau-Hyam, Marc

AU - Siskos, Alexandros P.

AU - Keun, Hector

AU - Botsivali, Maria

AU - de Kok, Theo M C M

AU - Pérez, Almudena Espín

AU - Kleinjans, Jos C S

AU - Vineis, Paolo

AU - Kyrtopoulos, Soterios A

AU - Gottschalk, Ralph

AU - Van Leeuwen, Danitsja

AU - Timmermans, Leen

AU - Bendinelli, Benedetta

AU - Kelly, Rachel S.

AU - Vermeulen, Roel

AU - Portengen, Lutzen

AU - Saberi-Hosnijeh, Fatemeh

AU - Melin, Beatrice

AU - Hallmans, Goran

AU - Lenner, Per

AU - Athersuch, Toby J.

AU - Kogevinas, Manolis

AU - Stephanou, Euripides G.

AU - Myridakis, Antonis

AU - Fazzo, Lucia

AU - De Santis, Marco

AU - Comba, Pietro

AU - Kiviranta, Hannu

AU - Rantakokko, Panu

AU - Airaksinen, Riikka

AU - Ruokojarvi, Paivi

AU - Gilthorpe, Mark

AU - Fleming, Sarah

AU - Fleming, Thomas D

AU - Tu, Yu Kang

AU - Jonsson, Bo A. G.

AU - Lundh, Thomas

AU - Chen, Wei J.

AU - Lee, Wen Chung

AU - Hsiao, Chuhsing Kate

AU - Chien, Kuo Liong

AU - Kuo, Po Hsiu

AU - Hung, Hung

AU - Liao, Shu Fen

PY - 2017/2/22

Y1 - 2017/2/22

N2 - We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 haem oxygenase 1) and BCL2L1 (BCL2- like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.

AB - We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 haem oxygenase 1) and BCL2L1 (BCL2- like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.

U2 - 10.1038/srep42870

DO - 10.1038/srep42870

M3 - Article

C2 - 28225026

SN - 2045-2322

VL - 7

JO - Scientific Reports

JF - Scientific Reports

M1 - 42870

ER -

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

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