Biosynthesis of tetronasin: Part 4, preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603)

Geert Jan Boons; J. Andrew Clase; Ian C. Lennon; Steven V. Ley; James Staunton

doi:10.1016/0040-4020(95)00201-I

Biosynthesis of tetronasin: Part 4, preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603)

Geert Jan Boons^*, J. Andrew Clase, Ian C. Lennon, Steven V. Ley, James Staunton

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Six deuterium labelled N-acylcysteamine polyketide derivatives (3) - (8) have been prepared as putative precursors for incorporation in studies of the biosynthesis of the ionophore antibiotic tetronasin (1). The route to these compounds was designed to be flexible and to maximise the use of common synthetic fragments.

Original language	English
Pages (from-to)	5417-5446
Number of pages	30
Journal	Tetrahedron
Volume	51
Issue number	18
DOIs	https://doi.org/10.1016/0040-4020(95)00201-I
Publication status	Published - 1 May 1995
Externally published	Yes

Funding

Acknowledgements: We thank the SERC (now the EPSRC) and Pfizer Central Research for financial support. We also acknowledge the Ramsay Memorial Fund (grant to GJB), the Natural Sciences and Engineering Research Council of Canada (grant to JAC) and British Petroleum for a research endowment to SVL at Cambridge.

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Boons, G. J., Andrew Clase, J., Lennon, I. C., Ley, S. V., & Staunton, J. (1995). Biosynthesis of tetronasin: Part 4, preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603). Tetrahedron, 51(18), 5417-5446. https://doi.org/10.1016/0040-4020(95)00201-I

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title = "Biosynthesis of tetronasin: Part 4, preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603)",

abstract = "Six deuterium labelled N-acylcysteamine polyketide derivatives (3) - (8) have been prepared as putative precursors for incorporation in studies of the biosynthesis of the ionophore antibiotic tetronasin (1). The route to these compounds was designed to be flexible and to maximise the use of common synthetic fragments.",

author = "Boons, {Geert Jan} and {Andrew Clase}, J. and Lennon, {Ian C.} and Ley, {Steven V.} and James Staunton",

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Boons, GJ, Andrew Clase, J, Lennon, IC, Ley, SV & Staunton, J 1995, 'Biosynthesis of tetronasin: Part 4, preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603)', Tetrahedron, vol. 51, no. 18, pp. 5417-5446. https://doi.org/10.1016/0040-4020(95)00201-I

Biosynthesis of tetronasin: Part 4, preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603). / Boons, Geert Jan; Andrew Clase, J.; Lennon, Ian C. et al.
In: Tetrahedron, Vol. 51, No. 18, 01.05.1995, p. 5417-5446.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Biosynthesis of tetronasin

T2 - Part 4, preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603)

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AU - Andrew Clase, J.

AU - Lennon, Ian C.

AU - Ley, Steven V.

AU - Staunton, James

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N2 - Six deuterium labelled N-acylcysteamine polyketide derivatives (3) - (8) have been prepared as putative precursors for incorporation in studies of the biosynthesis of the ionophore antibiotic tetronasin (1). The route to these compounds was designed to be flexible and to maximise the use of common synthetic fragments.

AB - Six deuterium labelled N-acylcysteamine polyketide derivatives (3) - (8) have been prepared as putative precursors for incorporation in studies of the biosynthesis of the ionophore antibiotic tetronasin (1). The route to these compounds was designed to be flexible and to maximise the use of common synthetic fragments.

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SN - 0040-4020

VL - 51

SP - 5417

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JO - Tetrahedron

JF - Tetrahedron

IS - 18

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Biosynthesis of tetronasin: Part 4, preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603)

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