Biological effect of interferon-γ during the course of experimental infection of rat by Schistosoma mansoni

Veronique Pancré; Huub Schellekens; Peter Van Der Meide; Han Vorng; Anne Delanoye; Andre Capron; Claude Auriault

doi:10.1016/0008-8749(90)90062-V

Biological effect of interferon-γ during the course of experimental infection of rat by Schistosoma mansoni

Veronique Pancré
, Huub Schellekens
, Peter Van Der Meide
, Han Vorng
, Anne Delanoye
, Andre Capron
, Claude Auriault

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We demonstrate here that a second mechanism of platelet activation dependent on lymphokine could also take place in the expression of platelet cytotoxicity against Schistosoma mansoni in vitro. Indeed, IgE, as previously described, but also IFN-γ, present in the sera of infected rats, together induce platelets from normal rats into cytotoxic effectors for the parasitic larvae. This second mechanism appears also effective in vivo since the passive transfer of normal platelets treated by recombinant IFN-γ (rIFN-γ) and the administration of rIFN-γ to rats conferred a protective immunity to S. mansoni.

Original language	English
Pages (from-to)	58-64
Number of pages	7
Journal	Cellular Immunology
Volume	125
Issue number	1
DOIs	https://doi.org/10.1016/0008-8749(90)90062-V
Publication status	Published - 1 Jan 1990
Externally published	Yes

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title = "Biological effect of interferon-γ during the course of experimental infection of rat by Schistosoma mansoni",

abstract = "We demonstrate here that a second mechanism of platelet activation dependent on lymphokine could also take place in the expression of platelet cytotoxicity against Schistosoma mansoni in vitro. Indeed, IgE, as previously described, but also IFN-γ, present in the sera of infected rats, together induce platelets from normal rats into cytotoxic effectors for the parasitic larvae. This second mechanism appears also effective in vivo since the passive transfer of normal platelets treated by recombinant IFN-γ (rIFN-γ) and the administration of rIFN-γ to rats conferred a protective immunity to S. mansoni.",

author = "Veronique Pancr{\'e} and Huub Schellekens and \{Van Der Meide\}, Peter and Han Vorng and Anne Delanoye and Andre Capron and Claude Auriault",

year = "1990",

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doi = "10.1016/0008-8749(90)90062-V",

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T1 - Biological effect of interferon-γ during the course of experimental infection of rat by Schistosoma mansoni

AU - Pancré, Veronique

AU - Schellekens, Huub

AU - Van Der Meide, Peter

AU - Vorng, Han

AU - Delanoye, Anne

AU - Capron, Andre

AU - Auriault, Claude

PY - 1990/1/1

Y1 - 1990/1/1

N2 - We demonstrate here that a second mechanism of platelet activation dependent on lymphokine could also take place in the expression of platelet cytotoxicity against Schistosoma mansoni in vitro. Indeed, IgE, as previously described, but also IFN-γ, present in the sera of infected rats, together induce platelets from normal rats into cytotoxic effectors for the parasitic larvae. This second mechanism appears also effective in vivo since the passive transfer of normal platelets treated by recombinant IFN-γ (rIFN-γ) and the administration of rIFN-γ to rats conferred a protective immunity to S. mansoni.

AB - We demonstrate here that a second mechanism of platelet activation dependent on lymphokine could also take place in the expression of platelet cytotoxicity against Schistosoma mansoni in vitro. Indeed, IgE, as previously described, but also IFN-γ, present in the sera of infected rats, together induce platelets from normal rats into cytotoxic effectors for the parasitic larvae. This second mechanism appears also effective in vivo since the passive transfer of normal platelets treated by recombinant IFN-γ (rIFN-γ) and the administration of rIFN-γ to rats conferred a protective immunity to S. mansoni.

UR - https://www.scopus.com/pages/publications/0025019534

U2 - 10.1016/0008-8749(90)90062-V

DO - 10.1016/0008-8749(90)90062-V

M3 - Article

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AN - SCOPUS:0025019534

SN - 0008-8749

VL - 125

SP - 58

EP - 64

JO - Cellular Immunology

JF - Cellular Immunology

IS - 1

ER -

Biological effect of interferon-γ during the course of experimental infection of rat by Schistosoma mansoni

Abstract

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