Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells

Akhilesh K Gaharwar; Silvia M Mihaila; Archana Swami; Alpesh Patel; Shilpa Sant; Rui L Reis; Alexandra P Marques; Manuela E Gomes; Ali Khademhosseini

doi:10.1002/adma.201300584

Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells

Akhilesh K Gaharwar
, Silvia M Mihaila
, Archana Swami
, Alpesh Patel
, Shilpa Sant
, Rui L Reis
, Alexandra P Marques
, Manuela E Gomes
, Ali Khademhosseini

Harvard Medical School
extern

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.

Original language	English
Pages (from-to)	3329-36
Number of pages	8
Journal	Advanced Materials
Volume	25
Issue number	24
DOIs	https://doi.org/10.1002/adma.201300584
Publication status	Published - 25 Jun 2013
Externally published	Yes

Bibliographical note

Keywords

Cell Differentiation
Cell Survival/drug effects
Cells, Cultured
Humans
Mesenchymal Stem Cells/cytology
Nanostructures/chemistry
Osteogenesis
Reactive Nitrogen Species/metabolism
Reactive Oxygen Species/metabolism
Silicates/chemistry
Tissue Engineering

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10.1002/adma.201300584

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title = "Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells",

abstract = "Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.",

keywords = "Cell Differentiation, Cell Survival/drug effects, Cells, Cultured, Humans, Mesenchymal Stem Cells/cytology, Nanostructures/chemistry, Osteogenesis, Reactive Nitrogen Species/metabolism, Reactive Oxygen Species/metabolism, Silicates/chemistry, Tissue Engineering",

author = "Gaharwar, \{Akhilesh K\} and Mihaila, \{Silvia M\} and Archana Swami and Alpesh Patel and Shilpa Sant and Reis, \{Rui L\} and Marques, \{Alexandra P\} and Gomes, \{Manuela E\} and Ali Khademhosseini",

note = "Copyright {\textcopyright} 2013 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2013",

month = jun,

day = "25",

doi = "10.1002/adma.201300584",

language = "English",

volume = "25",

pages = "3329--36",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells

AU - Gaharwar, Akhilesh K

AU - Mihaila, Silvia M

AU - Swami, Archana

AU - Patel, Alpesh

AU - Sant, Shilpa

AU - Reis, Rui L

AU - Marques, Alexandra P

AU - Gomes, Manuela E

AU - Khademhosseini, Ali

PY - 2013/6/25

Y1 - 2013/6/25

N2 - Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.

AB - Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.

KW - Cell Differentiation

KW - Cell Survival/drug effects

KW - Cells, Cultured

KW - Humans

KW - Mesenchymal Stem Cells/cytology

KW - Nanostructures/chemistry

KW - Osteogenesis

KW - Reactive Nitrogen Species/metabolism

KW - Reactive Oxygen Species/metabolism

KW - Silicates/chemistry

KW - Tissue Engineering

U2 - 10.1002/adma.201300584

DO - 10.1002/adma.201300584

M3 - Article

C2 - 23670944

SN - 0935-9648

VL - 25

SP - 3329

EP - 3336

JO - Advanced Materials

JF - Advanced Materials

IS - 24

ER -

Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells

Abstract

Bibliographical note

Keywords

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