Basepairing with 18S ribosomal RNA in internal initiation of translation

G C Scheper; H O Voorma; A A Thomas

Basepairing with 18S ribosomal RNA in internal initiation of translation

G C Scheper, H O Voorma, A A Thomas

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In concert with the translation initiation factors 'trans-acting' factors function specifically during internal initiation on picornaviral mRNAs. Of these trans-acting factors, two have been identified as the La-protein and the polypyrimidine tract binding protein. Within the internal ribosomal entry site on the viral RNA, sequences are present that direct the ribosome to the initiation codon. We suggest that selection of the correct AUG initiation codon occurs through basepairing with a part of 18S ribosomal RNA.

Original language	English
Pages (from-to)	271-5
Number of pages	5
Journal	FEBS Letters
Volume	352
Issue number	3
Publication status	Published - 1994

Keywords

Base Composition
Base Sequence
Codon
Molecular Sequence Data
Nucleic Acid Conformation
Picornaviridae
Protein Biosynthesis
RNA, Ribosomal, 18S
RNA, Transfer, Met
RNA, Viral

Cite this

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title = "Basepairing with 18S ribosomal RNA in internal initiation of translation",

abstract = "In concert with the translation initiation factors 'trans-acting' factors function specifically during internal initiation on picornaviral mRNAs. Of these trans-acting factors, two have been identified as the La-protein and the polypyrimidine tract binding protein. Within the internal ribosomal entry site on the viral RNA, sequences are present that direct the ribosome to the initiation codon. We suggest that selection of the correct AUG initiation codon occurs through basepairing with a part of 18S ribosomal RNA.",

keywords = "Base Composition, Base Sequence, Codon, Molecular Sequence Data, Nucleic Acid Conformation, Picornaviridae, Protein Biosynthesis, RNA, Ribosomal, 18S, RNA, Transfer, Met, RNA, Viral",

author = "Scheper, {G C} and Voorma, {H O} and Thomas, {A A}",

year = "1994",

language = "English",

volume = "352",

pages = "271--5",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "John Wiley and Sons Inc.",

number = "3",

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TY - JOUR

T1 - Basepairing with 18S ribosomal RNA in internal initiation of translation

AU - Scheper, G C

AU - Voorma, H O

AU - Thomas, A A

PY - 1994

Y1 - 1994

N2 - In concert with the translation initiation factors 'trans-acting' factors function specifically during internal initiation on picornaviral mRNAs. Of these trans-acting factors, two have been identified as the La-protein and the polypyrimidine tract binding protein. Within the internal ribosomal entry site on the viral RNA, sequences are present that direct the ribosome to the initiation codon. We suggest that selection of the correct AUG initiation codon occurs through basepairing with a part of 18S ribosomal RNA.

AB - In concert with the translation initiation factors 'trans-acting' factors function specifically during internal initiation on picornaviral mRNAs. Of these trans-acting factors, two have been identified as the La-protein and the polypyrimidine tract binding protein. Within the internal ribosomal entry site on the viral RNA, sequences are present that direct the ribosome to the initiation codon. We suggest that selection of the correct AUG initiation codon occurs through basepairing with a part of 18S ribosomal RNA.

KW - Base Composition

KW - Base Sequence

KW - Codon

KW - Molecular Sequence Data

KW - Nucleic Acid Conformation

KW - Picornaviridae

KW - Protein Biosynthesis

KW - RNA, Ribosomal, 18S

KW - RNA, Transfer, Met

KW - RNA, Viral

M3 - Article

C2 - 7925985

SN - 0014-5793

VL - 352

SP - 271

EP - 275

JO - FEBS Letters

JF - FEBS Letters

IS - 3

ER -

Basepairing with 18S ribosomal RNA in internal initiation of translation

Abstract

Keywords

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