Back Cover: DNP-Supported Solid-State NMR Spectroscopy of Proteins Inside Mammalian Cells (Angew. Chem. Int. Ed. 37/2019)

Siddarth Narasimhan; Stephan Scherpe; Alessandra Lucini Paioni; Johan van der Zwan; Gert E. Folkers; Huib Ovaa; Marc Baldus

doi:10.1002/anie.201908849

Back Cover: DNP-Supported Solid-State NMR Spectroscopy of Proteins Inside Mammalian Cells (Angew. Chem. Int. Ed. 37/2019)

Siddarth Narasimhan, Stephan Scherpe, Alessandra Lucini Paioni, Johan van der Zwan, Gert E. Folkers, Huib Ovaa, Marc Baldus

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Dynamic nuclear polarization (DNP) enhanced solid‐state NMR (ssNMR) spectroscopy enables atomic‐level structural studies of isotope labeled proteins at physiologically relevant concentrations in mammalian cells, irrespective of the tumbling rate of the protein of interest, as reported by H. Ovaa, M. Baldus, and co‐workers in their Communication on page 12969 ff. In the absence of DNP, NMR sensitivity levels are insufficient to conduct such studies.

Original language	English
Pages (from-to)	13162
Number of pages	1
Journal	Angewandte Chemie-International Edition
Volume	58
Issue number	37
DOIs	https://doi.org/10.1002/anie.201908849
Publication status	Published - 9 Sept 2019

Keywords

dynamic nuclear polarization
in-cell NMR
protein-protein interactions
solid-state NMR
ubiquitination

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Narasimhan_et_al-2019-Angewandte_Chemie_International_Edition (1)Final published version, 3.8 MBLicence: Taverne

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AU - Lucini Paioni, Alessandra

AU - van der Zwan, Johan

AU - Folkers, Gert E.

AU - Ovaa, Huib

AU - Baldus, Marc

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KW - dynamic nuclear polarization

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KW - protein-protein interactions

KW - solid-state NMR

KW - ubiquitination

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Back Cover: DNP-Supported Solid-State NMR Spectroscopy of Proteins Inside Mammalian Cells (Angew. Chem. Int. Ed. 37/2019)

Abstract

Keywords

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