Avian host defense peptides

Tryntsje Cuperus; M. Coorens; A. van Dijk; H.P. Haagsman

doi:10.1016/j.dci.2013.04.019

Avian host defense peptides

Tryntsje Cuperus, M. Coorens, A. van Dijk, H.P. Haagsman

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates.
These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs display
broad-spectrum antimicrobial activities and fulfill an important role in the first line of defense of many
organisms. It is becoming increasingly clear that in the animal kingdom the functions of HDPs are not
confined to direct antimicrobial actions. Research in mammals has indicated that HDPs have many
immunomodulatory functions and are also involved in other physiological processes ranging from development
to wound healing. During the past five years our knowledge about avian HDPs has increased considerably.
This review addresses our current knowledge on the evolution, regulation and biological
functions of HDPs of birds.

Original language	Undefined/Unknown
Pages (from-to)	352-369
Number of pages	18
Journal	Developmental and Comparative Immunology
Volume	41
DOIs	https://doi.org/10.1016/j.dci.2013.04.019
Publication status	Published - 2013

Keywords

Bird
Host defense
Defensin
Cathelicidin
Antibacterial
Immunomodulation

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10.1016/j.dci.2013.04.019

Embargoed Document

Cuperus et al 2013
Final published version, 2.2 MB
Embargo ends: 1/01/50

Cite this

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title = "Avian host defense peptides",

abstract = "Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates.These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs displaybroad-spectrum antimicrobial activities and fulfill an important role in the first line of defense of manyorganisms. It is becoming increasingly clear that in the animal kingdom the functions of HDPs are notconfined to direct antimicrobial actions. Research in mammals has indicated that HDPs have manyimmunomodulatory functions and are also involved in other physiological processes ranging from developmentto wound healing. During the past five years our knowledge about avian HDPs has increased considerably.This review addresses our current knowledge on the evolution, regulation and biologicalfunctions of HDPs of birds.",

keywords = "Bird, Host defense, Defensin, Cathelicidin, Antibacterial, Immunomodulation",

author = "Tryntsje Cuperus and M. Coorens and {van Dijk}, A. and H.P. Haagsman",

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doi = "10.1016/j.dci.2013.04.019",

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T1 - Avian host defense peptides

AU - Cuperus, Tryntsje

AU - Coorens, M.

AU - van Dijk, A.

AU - Haagsman, H.P.

PY - 2013

Y1 - 2013

N2 - Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates.These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs displaybroad-spectrum antimicrobial activities and fulfill an important role in the first line of defense of manyorganisms. It is becoming increasingly clear that in the animal kingdom the functions of HDPs are notconfined to direct antimicrobial actions. Research in mammals has indicated that HDPs have manyimmunomodulatory functions and are also involved in other physiological processes ranging from developmentto wound healing. During the past five years our knowledge about avian HDPs has increased considerably.This review addresses our current knowledge on the evolution, regulation and biologicalfunctions of HDPs of birds.

AB - Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates.These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs displaybroad-spectrum antimicrobial activities and fulfill an important role in the first line of defense of manyorganisms. It is becoming increasingly clear that in the animal kingdom the functions of HDPs are notconfined to direct antimicrobial actions. Research in mammals has indicated that HDPs have manyimmunomodulatory functions and are also involved in other physiological processes ranging from developmentto wound healing. During the past five years our knowledge about avian HDPs has increased considerably.This review addresses our current knowledge on the evolution, regulation and biologicalfunctions of HDPs of birds.

KW - Bird

KW - Host defense

KW - Defensin

KW - Cathelicidin

KW - Antibacterial

KW - Immunomodulation

U2 - 10.1016/j.dci.2013.04.019

DO - 10.1016/j.dci.2013.04.019

M3 - Article

SN - 0145-305X

VL - 41

SP - 352

EP - 369

JO - Developmental and Comparative Immunology

JF - Developmental and Comparative Immunology

ER -