Association of serum TNF-α, IL-8 and free light chain with HLA-DR B alleles expression in pulmonary and extra-pulmonary sarcoidosis

Esmaeil Mortaz; Hale Abdoli Sereshki; Atefeh Abedini; Arda Kiani; Mehdi Mirsaeidi; Dina Soroush; Johan Garssen; Aliakbar Velayati; Frank A Redegeld; Ian M Adcock

doi:10.1186/s12950-015-0066-3

Association of serum TNF-α, IL-8 and free light chain with HLA-DR B alleles expression in pulmonary and extra-pulmonary sarcoidosis

Esmaeil Mortaz, Hale Abdoli Sereshki, Atefeh Abedini, Arda Kiani, Mehdi Mirsaeidi, Dina Soroush, Johan Garssen, Aliakbar Velayati, Frank A Redegeld, Ian M Adcock

Pharmacology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Sarcoidosis is a systemic disease of unknown etiology characterized histologically by the observation of non-caseating granulomas and several immunological abnormalities. Sarcoidosis is a multi-organ disorder which involves formation of granulomas in many tissues including the lungs (pulmonary) and others such as skin, bone, heart (extra pulmonary). Associations between human leukocyte antigens (HLA), the encoded cell surface receptor (HLA-DR) and sarcoidosis have been reported in several studies. Several HLA-DR alleles have been described as potential risk factors for sarcoidosis in distinct ethnic groups however evidence for a relationship between HLA-DR alleles and pulmonary and extra-pulmonary sarcoidosis (EPS) is still scarce. Although the etiology of the disease remains unclear, infectious and environmental factors have been postulated. Inflammatory cytokines and chemokines may play important roles in the pathogenesis of sarcoidosis and serum free light chain (FLC) numbers have been implicated in several immunologic disorders.

PURPOSE OF THE STUDY: The aim of the present study was to investigate HLA associations with serum cytokines and FLC in Iranian patients with pulmonary (n = 86) and EPS (n = 46).

RESULTS: We found that among the 16 HLA DRB alleles only *7 and *12 were different in sarcoidosis patients. The levels of TNF-α and IL-8 in pulmonary sarcoidosis patients were higher than in EPS (P < 0.05) whereas the levels of FLC subunits in EPS were higher than in pulmonary sarcoidosis.

CONCLUSION: This data may suggests a link between HLA-DRB *12 and sarcoidosis in Iranian population.

Original language	English
Article number	12:21
Journal	Journal of Inflammation (BioMed Central)
Volume	12
DOIs	https://doi.org/10.1186/s12950-015-0066-3
Publication status	Published - 2015

Keywords

Sarcoidosis
HLA-DR
TNF-α
IL-8

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12950-015-0066-3

12950_2015_Article_66Final published version, 826 KB

Cite this

Mortaz, E., Sereshki, H. A., Abedini, A., Kiani, A., Mirsaeidi, M., Soroush, D., Garssen, J., Velayati, A., Redegeld, F. A., & Adcock, I. M. (2015). Association of serum TNF-α, IL-8 and free light chain with HLA-DR B alleles expression in pulmonary and extra-pulmonary sarcoidosis. Journal of Inflammation (BioMed Central), 12, Article 12:21. https://doi.org/10.1186/s12950-015-0066-3

@article{2238ffa506544a5fa669773f2e65aa25,

title = "Association of serum TNF-α, IL-8 and free light chain with HLA-DR B alleles expression in pulmonary and extra-pulmonary sarcoidosis",

abstract = "BACKGROUND: Sarcoidosis is a systemic disease of unknown etiology characterized histologically by the observation of non-caseating granulomas and several immunological abnormalities. Sarcoidosis is a multi-organ disorder which involves formation of granulomas in many tissues including the lungs (pulmonary) and others such as skin, bone, heart (extra pulmonary). Associations between human leukocyte antigens (HLA), the encoded cell surface receptor (HLA-DR) and sarcoidosis have been reported in several studies. Several HLA-DR alleles have been described as potential risk factors for sarcoidosis in distinct ethnic groups however evidence for a relationship between HLA-DR alleles and pulmonary and extra-pulmonary sarcoidosis (EPS) is still scarce. Although the etiology of the disease remains unclear, infectious and environmental factors have been postulated. Inflammatory cytokines and chemokines may play important roles in the pathogenesis of sarcoidosis and serum free light chain (FLC) numbers have been implicated in several immunologic disorders.PURPOSE OF THE STUDY: The aim of the present study was to investigate HLA associations with serum cytokines and FLC in Iranian patients with pulmonary (n = 86) and EPS (n = 46).RESULTS: We found that among the 16 HLA DRB alleles only *7 and *12 were different in sarcoidosis patients. The levels of TNF-α and IL-8 in pulmonary sarcoidosis patients were higher than in EPS (P < 0.05) whereas the levels of FLC subunits in EPS were higher than in pulmonary sarcoidosis.CONCLUSION: This data may suggests a link between HLA-DRB *12 and sarcoidosis in Iranian population.",

keywords = "Sarcoidosis, HLA-DR, TNF-α, IL-8",

author = "Esmaeil Mortaz and Sereshki, {Hale Abdoli} and Atefeh Abedini and Arda Kiani and Mehdi Mirsaeidi and Dina Soroush and Johan Garssen and Aliakbar Velayati and Redegeld, {Frank A} and Adcock, {Ian M}",

year = "2015",

doi = "10.1186/s12950-015-0066-3",

language = "English",

volume = "12",

journal = "Journal of Inflammation (BioMed Central)",

issn = "1476-9255",

publisher = "BioMed Central",

}

TY - JOUR

T1 - Association of serum TNF-α, IL-8 and free light chain with HLA-DR B alleles expression in pulmonary and extra-pulmonary sarcoidosis

AU - Mortaz, Esmaeil

AU - Sereshki, Hale Abdoli

AU - Abedini, Atefeh

AU - Kiani, Arda

AU - Mirsaeidi, Mehdi

AU - Soroush, Dina

AU - Garssen, Johan

AU - Velayati, Aliakbar

AU - Redegeld, Frank A

AU - Adcock, Ian M

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Sarcoidosis is a systemic disease of unknown etiology characterized histologically by the observation of non-caseating granulomas and several immunological abnormalities. Sarcoidosis is a multi-organ disorder which involves formation of granulomas in many tissues including the lungs (pulmonary) and others such as skin, bone, heart (extra pulmonary). Associations between human leukocyte antigens (HLA), the encoded cell surface receptor (HLA-DR) and sarcoidosis have been reported in several studies. Several HLA-DR alleles have been described as potential risk factors for sarcoidosis in distinct ethnic groups however evidence for a relationship between HLA-DR alleles and pulmonary and extra-pulmonary sarcoidosis (EPS) is still scarce. Although the etiology of the disease remains unclear, infectious and environmental factors have been postulated. Inflammatory cytokines and chemokines may play important roles in the pathogenesis of sarcoidosis and serum free light chain (FLC) numbers have been implicated in several immunologic disorders.PURPOSE OF THE STUDY: The aim of the present study was to investigate HLA associations with serum cytokines and FLC in Iranian patients with pulmonary (n = 86) and EPS (n = 46).RESULTS: We found that among the 16 HLA DRB alleles only *7 and *12 were different in sarcoidosis patients. The levels of TNF-α and IL-8 in pulmonary sarcoidosis patients were higher than in EPS (P < 0.05) whereas the levels of FLC subunits in EPS were higher than in pulmonary sarcoidosis.CONCLUSION: This data may suggests a link between HLA-DRB *12 and sarcoidosis in Iranian population.

AB - BACKGROUND: Sarcoidosis is a systemic disease of unknown etiology characterized histologically by the observation of non-caseating granulomas and several immunological abnormalities. Sarcoidosis is a multi-organ disorder which involves formation of granulomas in many tissues including the lungs (pulmonary) and others such as skin, bone, heart (extra pulmonary). Associations between human leukocyte antigens (HLA), the encoded cell surface receptor (HLA-DR) and sarcoidosis have been reported in several studies. Several HLA-DR alleles have been described as potential risk factors for sarcoidosis in distinct ethnic groups however evidence for a relationship between HLA-DR alleles and pulmonary and extra-pulmonary sarcoidosis (EPS) is still scarce. Although the etiology of the disease remains unclear, infectious and environmental factors have been postulated. Inflammatory cytokines and chemokines may play important roles in the pathogenesis of sarcoidosis and serum free light chain (FLC) numbers have been implicated in several immunologic disorders.PURPOSE OF THE STUDY: The aim of the present study was to investigate HLA associations with serum cytokines and FLC in Iranian patients with pulmonary (n = 86) and EPS (n = 46).RESULTS: We found that among the 16 HLA DRB alleles only *7 and *12 were different in sarcoidosis patients. The levels of TNF-α and IL-8 in pulmonary sarcoidosis patients were higher than in EPS (P < 0.05) whereas the levels of FLC subunits in EPS were higher than in pulmonary sarcoidosis.CONCLUSION: This data may suggests a link between HLA-DRB *12 and sarcoidosis in Iranian population.

KW - Sarcoidosis

KW - HLA-DR

KW - TNF-α

KW - IL-8

U2 - 10.1186/s12950-015-0066-3

DO - 10.1186/s12950-015-0066-3

M3 - Article

C2 - 25866481

SN - 1476-9255

VL - 12

JO - Journal of Inflammation (BioMed Central)

JF - Journal of Inflammation (BioMed Central)

M1 - 12:21

ER -

Association of serum TNF-α, IL-8 and free light chain with HLA-DR B alleles expression in pulmonary and extra-pulmonary sarcoidosis

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this