Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts

Cornelis P M Veth; Martijn Arns; Wilhelmus Drinkenburg; Willem Talloen; Pieter J. Peeters; Evian Gordon; Jan K. Buitelaar

doi:10.1016/j.psychres.2014.05.021

Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts

Cornelis P M Veth^*
, Martijn Arns
, Wilhelmus Drinkenburg
, Willem Talloen
, Pieter J. Peeters
, Evian Gordon
, Jan K. Buitelaar

^*Corresponding author for this work

Radboud University Medical Center, Department of Psychiatry, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Research Institute Brainclinics, Bijleveldsingel 34, 6524 AD Nijmegen, The Netherlands
Janssen Research and Development, Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium
Brain Resource Limited, Level 12, 235 Jones St. Ultimo, NSW 2007, Australia

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects.

Original language	English
Pages (from-to)	221-224
Number of pages	4
Journal	Psychiatry Research
Volume	219
Issue number	1
DOIs	https://doi.org/10.1016/j.psychres.2014.05.021
Publication status	Published - 30 Sept 2014

Funding

We thank Brain Resource Company and Johnson & Johnson for allowing the use of these data for this study and Michelle Wang from Brainnet. Data and support was provided by BRAINnet; www.BRAINnet.net , under the governance of the BRAINnet foundation. BRAINnet is the scientific network that coordinates access to the Brain Resource International Database for independent scientific purposes. Further, we thank Carol Dobson-Stone and Peter R. Schofield for providing the genotyping data. Appendix A

Keywords

Catechol-O-Methyltransferase Val158Met polymorphism
Electroencephalographic alpha peak frequency
Major depressive disorder

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2014.05.021

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title = "Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts",

abstract = "This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects.",

keywords = "Catechol-O-Methyltransferase Val158Met polymorphism, Electroencephalographic alpha peak frequency, Major depressive disorder",

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AU - Veth, Cornelis P M

AU - Arns, Martijn

AU - Drinkenburg, Wilhelmus

AU - Talloen, Willem

AU - Peeters, Pieter J.

AU - Gordon, Evian

AU - Buitelaar, Jan K.

PY - 2014/9/30

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N2 - This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects.

AB - This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects.

KW - Catechol-O-Methyltransferase Val158Met polymorphism

KW - Electroencephalographic alpha peak frequency

KW - Major depressive disorder

UR - https://www.scopus.com/pages/publications/84902551979

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DO - 10.1016/j.psychres.2014.05.021

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AN - SCOPUS:84902551979

SN - 0165-1781

VL - 219

SP - 221

EP - 224

JO - Psychiatry Research

JF - Psychiatry Research

IS - 1

ER -

Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts

Abstract

Funding

Keywords

UN SDGs

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