Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts

Cornelis P M Veth; Martijn Arns; Wilhelmus Drinkenburg; Willem Talloen; Pieter J. Peeters; Evian Gordon; Jan K. Buitelaar

doi:10.1016/j.psychres.2014.05.021

Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts

Cornelis P M Veth^*, Martijn Arns, Wilhelmus Drinkenburg, Willem Talloen, Pieter J. Peeters, Evian Gordon, Jan K. Buitelaar

^*Corresponding author for this work

Radboud University Medical Center, Department of Psychiatry, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Research Institute Brainclinics, Bijleveldsingel 34, 6524 AD Nijmegen, The Netherlands
Janssen Research and Development, Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium
Brain Resource Limited, Level 12, 235 Jones St. Ultimo, NSW 2007, Australia

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects.

Original language	English
Pages (from-to)	221-224
Number of pages	4
Journal	Psychiatry Research
Volume	219
Issue number	1
DOIs	https://doi.org/10.1016/j.psychres.2014.05.021
Publication status	Published - 30 Sept 2014

Keywords

Catechol-O-Methyltransferase Val158Met polymorphism
Electroencephalographic alpha peak frequency
Major depressive disorder

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10.1016/j.psychres.2014.05.021

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abstract = "This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects.",

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AU - Drinkenburg, Wilhelmus

AU - Talloen, Willem

AU - Peeters, Pieter J.

AU - Gordon, Evian

AU - Buitelaar, Jan K.

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AB - This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects.

KW - Catechol-O-Methyltransferase Val158Met polymorphism

KW - Electroencephalographic alpha peak frequency

KW - Major depressive disorder

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Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts

Abstract

Keywords

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