Artificial Metalloenzymes for Hydrogenation and Transfer Hydrogenation Reactions

Manuel Basauri-molina, Robertus J. M. Klein Gebbink

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic


The development of artificial hydrogenases (AHases) and transfer hydrogenases (ATHases) has played a leading and guiding role for the field of artificial metalloenzymes. Starting from the early studies by Whitesides and coworkers, this chapter showcases the conceptual development of AHases and ATHases, highlighting the different conjugation strategies used for their construction and exemplifying the stereoselective control in product formation that can be reached.
Original languageEnglish
Title of host publicationArtificial Metalloenzymes and MetalloDNAzymes in Catalysis
Subtitle of host publicationFrom Design to Applications
PublisherWiley - VCH Verlag GmbH & CO. KGaA
ISBN (Electronic)9783527804085
ISBN (Print)9783527341788
Publication statusPublished - 25 Mar 2018


  • artificial metalloenzymes
  • catalytic hydrogenation
  • transfer hydrogenation
  • directed evolution
  • enantioselectivity
  • rhodium
  • ruthenium
  • iridium


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