TY - JOUR
T1 - Archaeogenetic analysis of Neolithic sheep from Anatolia suggests a complex demographic history since domestication
AU - Yurtman, Erinç
AU - Özer, Onur
AU - Yüncü, Eren
AU - Dağtaş, Nihan Dilşad
AU - Koptekin, Dilek
AU - Çakan, Yasin Gökhan
AU - Özkan, Mustafa
AU - Akbaba, Ali
AU - Kaptan, Damla
AU - Atağ, Gözde
AU - Vural, Kıvılcım Başak
AU - Gündem, Can Yümni
AU - Martin, Louise
AU - Kılınç, Gülşah Merve
AU - Ghalichi, Ayshin
AU - Açan, Sinan Can
AU - Yaka, Reyhan
AU - Sağlıcan, Ekin
AU - Lagerholm, Vendela Kempe
AU - Krzewińska, Maja
AU - Günther, Torsten
AU - Morell Miranda, Pedro
AU - Pişkin, Evangelia
AU - Şevketoğlu, Müge
AU - Bilgin, C Can
AU - Atakuman, Çiğdem
AU - Erdal, Yılmaz Selim
AU - Sürer, Elif
AU - Altınışık, N Ezgi
AU - Lenstra, Johannes A
AU - Yorulmaz, Sevgi
AU - Abazari, Mohammad Foad
AU - Hoseinzadeh, Javad
AU - Baird, Douglas
AU - Bıçakçı, Erhan
AU - Çevik, Özlem
AU - Gerritsen, Fokke
AU - Özbal, Rana
AU - Götherström, Anders
AU - Somel, Mehmet
AU - Togan, İnci
AU - Özer, Füsun
N1 - Funding Information:
We are grateful to the METU CompEvo group, Daniel Bradley, Arpat Özgül, Cosimo Posth, and three anonymous reviewers for support, helpful suggestions, and/or comments. This work was supported by TÜBİTAK 1001 (Project No: 111T464 and 114Z356) and ERC Consolidator grant “NEOGENE” (Project No.: 772390).
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Sheep were among the first domesticated animals, but their demographic history is little understood. Here we analyzed nuclear polymorphism and mitochondrial data (mtDNA) from ancient central and west Anatolian sheep dating from Epipaleolithic to late Neolithic, comparatively with modern-day breeds and central Asian Neolithic/Bronze Age sheep (OBI). Analyzing ancient nuclear data, we found that Anatolian Neolithic sheep (ANS) are genetically closest to present-day European breeds relative to Asian breeds, a conclusion supported by mtDNA haplogroup frequencies. In contrast, OBI showed higher genetic affinity to present-day Asian breeds. These results suggest that the east-west genetic structure observed in present-day breeds had already emerged by 6000 BCE, hinting at multiple sheep domestication episodes or early wild introgression in southwest Asia. Furthermore, we found that ANS are genetically distinct from all modern breeds. Our results suggest that European and Anatolian domestic sheep gene pools have been strongly remolded since the Neolithic.
AB - Sheep were among the first domesticated animals, but their demographic history is little understood. Here we analyzed nuclear polymorphism and mitochondrial data (mtDNA) from ancient central and west Anatolian sheep dating from Epipaleolithic to late Neolithic, comparatively with modern-day breeds and central Asian Neolithic/Bronze Age sheep (OBI). Analyzing ancient nuclear data, we found that Anatolian Neolithic sheep (ANS) are genetically closest to present-day European breeds relative to Asian breeds, a conclusion supported by mtDNA haplogroup frequencies. In contrast, OBI showed higher genetic affinity to present-day Asian breeds. These results suggest that the east-west genetic structure observed in present-day breeds had already emerged by 6000 BCE, hinting at multiple sheep domestication episodes or early wild introgression in southwest Asia. Furthermore, we found that ANS are genetically distinct from all modern breeds. Our results suggest that European and Anatolian domestic sheep gene pools have been strongly remolded since the Neolithic.
UR - https://www.scopus.com/pages/publications/85118997892
U2 - 10.1038/s42003-021-02794-8
DO - 10.1038/s42003-021-02794-8
M3 - Article
C2 - 34773064
SN - 2399-3642
VL - 4
SP - 1
EP - 11
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 1279
ER -