Abstract
Abstract The leading cause of hepatic damage is drug-induced liver injury (DILI), for which currently no adequate predictive biomarkers are available. Moreover, for most drugs related to DILI, the mechanisms underlying the adverse reaction have not yet been elucidated. Urinary protein biomarker candidates for DILI have emerged in the past few years and correlate well with clinical studies for serum DILI biomarkers. The goal of this review was to investigate the use of urine as a source of protein biomarkers for drug-induced liver injury. Finally, we discuss some of the current strategies required to advance the field of biomarker discovery for DILI with respect to appropriate clinical biobanking and adequate translational research.
| Original language | English |
|---|---|
| Pages (from-to) | 823-41 |
| Number of pages | 19 |
| Journal | Critical Reviews in Toxicology |
| Volume | 44 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Nov 2014 |
Keywords
- Animals
- Biological Markers
- Disease Models, Animal
- Drug-Induced Liver Injury
- Humans
- Proteomics
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