Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68

Liang Sun; Adam Meijer; Mathy Froeyen; Linlin Zhang; Hendrik Jan Thibaut; Jim Baggen; Shyla George; John Vernachio; Frank J M van Kuppeveld; Pieter Leyssen; Rolf Hilgenfeld; Johan Neyts; Leen Delang

doi:10.1128/AAC.01375-15

Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68

Liang Sun
, Adam Meijer
, Mathy Froeyen
, Linlin Zhang
, Hendrik Jan Thibaut
, Jim Baggen
, Shyla George
, John Vernachio
, Frank J M van Kuppeveld
, Pieter Leyssen
, Rolf Hilgenfeld
, Johan Neyts
, Leen Delang

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The susceptibility of ten EV-68 isolates (belonging to cluster A, B and C) to (entero-)virus inhibitors with different mechanisms of action was investigated. The 3C-protease inhibitors proved to be more efficient than enviroxime and pleconaril, which in turn were more effective than vapendavir and pirodavir. Favipiravir proved a weak inhibitor. Resistance to pleconaril maps to V69A in VP1 and resistance to rupintrivir to V104I in the 3C protease. A structural explanation is provided why both mutations may cause resistance.

Original language	English
Pages (from-to)	7782-7785
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	12
DOIs	https://doi.org/10.1128/AAC.01375-15
Publication status	Published - 14 Sept 2015

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Sun, L., Meijer, A., Froeyen, M., Zhang, L., Thibaut, H. J., Baggen, J., George, S., Vernachio, J., van Kuppeveld, F. J. M., Leyssen, P., Hilgenfeld, R., Neyts, J., & Delang, L. (2015). Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68. Antimicrobial Agents and Chemotherapy, 59(12), 7782-7785. https://doi.org/10.1128/AAC.01375-15

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abstract = "The susceptibility of ten EV-68 isolates (belonging to cluster A, B and C) to (entero-)virus inhibitors with different mechanisms of action was investigated. The 3C-protease inhibitors proved to be more efficient than enviroxime and pleconaril, which in turn were more effective than vapendavir and pirodavir. Favipiravir proved a weak inhibitor. Resistance to pleconaril maps to V69A in VP1 and resistance to rupintrivir to V104I in the 3C protease. A structural explanation is provided why both mutations may cause resistance.",

author = "Liang Sun and Adam Meijer and Mathy Froeyen and Linlin Zhang and Thibaut, \{Hendrik Jan\} and Jim Baggen and Shyla George and John Vernachio and \{van Kuppeveld\}, \{Frank J M\} and Pieter Leyssen and Rolf Hilgenfeld and Johan Neyts and Leen Delang",

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Sun, L, Meijer, A, Froeyen, M, Zhang, L, Thibaut, HJ, Baggen, J, George, S, Vernachio, J, van Kuppeveld, FJM, Leyssen, P, Hilgenfeld, R, Neyts, J & Delang, L 2015, 'Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68', Antimicrobial Agents and Chemotherapy, vol. 59, no. 12, pp. 7782-7785. https://doi.org/10.1128/AAC.01375-15

TY - JOUR

T1 - Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68

AU - Sun, Liang

AU - Meijer, Adam

AU - Froeyen, Mathy

AU - Zhang, Linlin

AU - Thibaut, Hendrik Jan

AU - Baggen, Jim

AU - George, Shyla

AU - Vernachio, John

AU - van Kuppeveld, Frank J M

AU - Leyssen, Pieter

AU - Hilgenfeld, Rolf

AU - Neyts, Johan

AU - Delang, Leen

PY - 2015/9/14

Y1 - 2015/9/14

N2 - The susceptibility of ten EV-68 isolates (belonging to cluster A, B and C) to (entero-)virus inhibitors with different mechanisms of action was investigated. The 3C-protease inhibitors proved to be more efficient than enviroxime and pleconaril, which in turn were more effective than vapendavir and pirodavir. Favipiravir proved a weak inhibitor. Resistance to pleconaril maps to V69A in VP1 and resistance to rupintrivir to V104I in the 3C protease. A structural explanation is provided why both mutations may cause resistance.

AB - The susceptibility of ten EV-68 isolates (belonging to cluster A, B and C) to (entero-)virus inhibitors with different mechanisms of action was investigated. The 3C-protease inhibitors proved to be more efficient than enviroxime and pleconaril, which in turn were more effective than vapendavir and pirodavir. Favipiravir proved a weak inhibitor. Resistance to pleconaril maps to V69A in VP1 and resistance to rupintrivir to V104I in the 3C protease. A structural explanation is provided why both mutations may cause resistance.

U2 - 10.1128/AAC.01375-15

DO - 10.1128/AAC.01375-15

M3 - Article

C2 - 26369972

SN - 0066-4804

VL - 59

SP - 7782

EP - 7785

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 12

ER -

Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68

Abstract

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