TY - JOUR
T1 - Anorexia nervosa and the Val158Met polymorphism of the COMT gene
T2 - meta-analysis and new data
AU - Brandys, Marek K
AU - Slof-Op't Landt, Margarita C T
AU - van Elburg, Annemarie A
AU - Ophoff, Roel
AU - Verduijn, Willem
AU - Meulenbelt, Ingrid
AU - Middeldorp, Christel M
AU - Boomsma, Dorret I
AU - van Furth, Eric F
AU - Slagboom, Eline
AU - Kas, Martien J H
AU - Adan, Roger A H
PY - 2012/6
Y1 - 2012/6
N2 - OBJECTIVES: This study aimed to test the association between the Val158Met polymorphism (rs4680) of the catechol-O-methyl transferase gene and anorexia nervosa (AN).METHODS: First, an association study on two cohorts (306 cases and 1009 controls from Utrecht, and 174 cases and 466 controls from Leiden/NTR) was performed. Subsequently, the results were integrated into a meta-analysis, together with all the case-control and family-based studies, which were testing the same hypothesis and were available in the literature. Altogether, eight studies (11 datasets) were included in this meta-analysis, with a total of 2021 cases, 2848 controls, and 89 informative (heterozygous) trios.RESULTS: The present association studies found no association between AN and rs4680 when testing the allelic contrast [Utrecht odds ratio (OR)=1.14, P=0.14; Leiden OR=1.02, P=0.85]. There was an indication of an association under the dominant model of genetic effect in the Utrecht cohort (for the Met allele, OR=1.42, P=0.03). Nevertheless, the meta-analyses of both the allelic contrast and the dominant effect were nonsignificant (the allelic pooled OR=1.03, P=0.42 and the dominant pooled OR=1.1, P=0.18). The meta-analyses were performed under the fixed-effect model and there was no significant heterogeneity among the effect sizes.CONCLUSION: Meta-analytically combined evidence from the present genotypings and the literature search shows that the effect sizes are homogeneous across studies and that rs4680 is not associated with AN.
AB - OBJECTIVES: This study aimed to test the association between the Val158Met polymorphism (rs4680) of the catechol-O-methyl transferase gene and anorexia nervosa (AN).METHODS: First, an association study on two cohorts (306 cases and 1009 controls from Utrecht, and 174 cases and 466 controls from Leiden/NTR) was performed. Subsequently, the results were integrated into a meta-analysis, together with all the case-control and family-based studies, which were testing the same hypothesis and were available in the literature. Altogether, eight studies (11 datasets) were included in this meta-analysis, with a total of 2021 cases, 2848 controls, and 89 informative (heterozygous) trios.RESULTS: The present association studies found no association between AN and rs4680 when testing the allelic contrast [Utrecht odds ratio (OR)=1.14, P=0.14; Leiden OR=1.02, P=0.85]. There was an indication of an association under the dominant model of genetic effect in the Utrecht cohort (for the Met allele, OR=1.42, P=0.03). Nevertheless, the meta-analyses of both the allelic contrast and the dominant effect were nonsignificant (the allelic pooled OR=1.03, P=0.42 and the dominant pooled OR=1.1, P=0.18). The meta-analyses were performed under the fixed-effect model and there was no significant heterogeneity among the effect sizes.CONCLUSION: Meta-analytically combined evidence from the present genotypings and the literature search shows that the effect sizes are homogeneous across studies and that rs4680 is not associated with AN.
KW - Anorexia Nervosa
KW - Case-Control Studies
KW - Catechol O-Methyltransferase
KW - Female
KW - Humans
KW - Male
KW - Methionine
KW - Polymorphism, Genetic
KW - Valine
U2 - 10.1097/YPG.0b013e328351859e
DO - 10.1097/YPG.0b013e328351859e
M3 - Article
C2 - 22366815
SN - 0955-8829
VL - 22
SP - 130
EP - 136
JO - Psychiatric Genetics
JF - Psychiatric Genetics
IS - 3
ER -