An outbreak of Shigella boydii serotype 20 in January 2015 amongst United Kingdom healthcare workers involved in the Ebola response in Sierra Leone

Daniel Todkill; Rachel Pudney; Andrew Terrell; Jerry Tuck; Emma Hutley; Timothy J Dallman; Claire Jenkins; Rohini Manuel; Michael Wade; Richard Puleston; Jeremy Hawker

doi:10.1099/jmm.0.000832

An outbreak of Shigella boydii serotype 20 in January 2015 amongst United Kingdom healthcare workers involved in the Ebola response in Sierra Leone

Daniel Todkill
, Rachel Pudney
, Andrew Terrell
, Jerry Tuck
, Emma Hutley
, Timothy J Dallman
, Claire Jenkins
, Rohini Manuel
, Michael Wade
, Richard Puleston
, Jeremy Hawker

National Infection Service
DMS Whittington
extern
Public Health England

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In January 2015, Public Health England and the United Kingdom (UK) Ministry of Defence investigated cases of diarrhoea and fever in military personnel recently returned to the UK after supporting the response to the Ebola epidemic in Sierra Leone. Tests for Ebola virus infection were negative. PCR tests detected the ipaH gene in 10/12 faecal specimens, and Shigella boydii serotype 20 was isolated from 7 patients. A case control study was undertaken and analysed using multivariable logistic regression. Consumption of a coronation chicken lunch at the transit camp in Sierra Leone (SL) 24-48 h prior to departure for the UK was significantly associated with disease [adjusted odds ratio (OR) 28.15, 95 % CI: 1.87-422.65]. In the context of heightened concern during the Ebola epidemic, this outbreak highlights the importance of rapid and effective microbiological and epidemiological investigations to identify the aetiological agent in patients presenting with fever and diarrhoea.

Original language	English
Pages (from-to)	1596-1600
Number of pages	5
Journal	Journal of Medical Microbiology
Volume	67
Issue number	11
DOIs	https://doi.org/10.1099/jmm.0.000832
Publication status	Published - Nov 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Animals
Bacterial Proteins/genetics
Case-Control Studies
Chickens/microbiology
Communicable Diseases, Imported/epidemiology
Disease Outbreaks
Dysentery, Bacillary/epidemiology
Feces/microbiology
Female
Fever/epidemiology
Food Contamination
Health Personnel
Hemorrhagic Fever, Ebola/epidemiology
Humans
International Cooperation
Male
Military Personnel
Serogroup
Shigella boydii/classification
Sierra Leone/epidemiology
United Kingdom/epidemiology
Whole Genome Sequencing
Young Adult

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10.1099/jmm.0.000832

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Todkill, D., Pudney, R., Terrell, A., Tuck, J., Hutley, E., Dallman, T. J., Jenkins, C., Manuel, R., Wade, M., Puleston, R., & Hawker, J. (2018). An outbreak of Shigella boydii serotype 20 in January 2015 amongst United Kingdom healthcare workers involved in the Ebola response in Sierra Leone. Journal of Medical Microbiology, 67(11), 1596-1600. https://doi.org/10.1099/jmm.0.000832

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title = "An outbreak of Shigella boydii serotype 20 in January 2015 amongst United Kingdom healthcare workers involved in the Ebola response in Sierra Leone",

abstract = "In January 2015, Public Health England and the United Kingdom (UK) Ministry of Defence investigated cases of diarrhoea and fever in military personnel recently returned to the UK after supporting the response to the Ebola epidemic in Sierra Leone. Tests for Ebola virus infection were negative. PCR tests detected the ipaH gene in 10/12 faecal specimens, and Shigella boydii serotype 20 was isolated from 7 patients. A case control study was undertaken and analysed using multivariable logistic regression. Consumption of a coronation chicken lunch at the transit camp in Sierra Leone (SL) 24-48 h prior to departure for the UK was significantly associated with disease [adjusted odds ratio (OR) 28.15, 95 \% CI: 1.87-422.65]. In the context of heightened concern during the Ebola epidemic, this outbreak highlights the importance of rapid and effective microbiological and epidemiological investigations to identify the aetiological agent in patients presenting with fever and diarrhoea.",

keywords = "Adult, Animals, Bacterial Proteins/genetics, Case-Control Studies, Chickens/microbiology, Communicable Diseases, Imported/epidemiology, Disease Outbreaks, Dysentery, Bacillary/epidemiology, Feces/microbiology, Female, Fever/epidemiology, Food Contamination, Health Personnel, Hemorrhagic Fever, Ebola/epidemiology, Humans, International Cooperation, Male, Military Personnel, Serogroup, Shigella boydii/classification, Sierra Leone/epidemiology, United Kingdom/epidemiology, Whole Genome Sequencing, Young Adult",

author = "Daniel Todkill and Rachel Pudney and Andrew Terrell and Jerry Tuck and Emma Hutley and Dallman, \{Timothy J\} and Claire Jenkins and Rohini Manuel and Michael Wade and Richard Puleston and Jeremy Hawker",

year = "2018",

month = nov,

doi = "10.1099/jmm.0.000832",

language = "English",

volume = "67",

pages = "1596--1600",

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Todkill, D, Pudney, R, Terrell, A, Tuck, J, Hutley, E, Dallman, TJ, Jenkins, C, Manuel, R, Wade, M, Puleston, R & Hawker, J 2018, 'An outbreak of Shigella boydii serotype 20 in January 2015 amongst United Kingdom healthcare workers involved in the Ebola response in Sierra Leone', Journal of Medical Microbiology, vol. 67, no. 11, pp. 1596-1600. https://doi.org/10.1099/jmm.0.000832

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AU - Todkill, Daniel

AU - Pudney, Rachel

AU - Terrell, Andrew

AU - Tuck, Jerry

AU - Hutley, Emma

AU - Dallman, Timothy J

AU - Jenkins, Claire

AU - Manuel, Rohini

AU - Wade, Michael

AU - Puleston, Richard

AU - Hawker, Jeremy

PY - 2018/11

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N2 - In January 2015, Public Health England and the United Kingdom (UK) Ministry of Defence investigated cases of diarrhoea and fever in military personnel recently returned to the UK after supporting the response to the Ebola epidemic in Sierra Leone. Tests for Ebola virus infection were negative. PCR tests detected the ipaH gene in 10/12 faecal specimens, and Shigella boydii serotype 20 was isolated from 7 patients. A case control study was undertaken and analysed using multivariable logistic regression. Consumption of a coronation chicken lunch at the transit camp in Sierra Leone (SL) 24-48 h prior to departure for the UK was significantly associated with disease [adjusted odds ratio (OR) 28.15, 95 % CI: 1.87-422.65]. In the context of heightened concern during the Ebola epidemic, this outbreak highlights the importance of rapid and effective microbiological and epidemiological investigations to identify the aetiological agent in patients presenting with fever and diarrhoea.

AB - In January 2015, Public Health England and the United Kingdom (UK) Ministry of Defence investigated cases of diarrhoea and fever in military personnel recently returned to the UK after supporting the response to the Ebola epidemic in Sierra Leone. Tests for Ebola virus infection were negative. PCR tests detected the ipaH gene in 10/12 faecal specimens, and Shigella boydii serotype 20 was isolated from 7 patients. A case control study was undertaken and analysed using multivariable logistic regression. Consumption of a coronation chicken lunch at the transit camp in Sierra Leone (SL) 24-48 h prior to departure for the UK was significantly associated with disease [adjusted odds ratio (OR) 28.15, 95 % CI: 1.87-422.65]. In the context of heightened concern during the Ebola epidemic, this outbreak highlights the importance of rapid and effective microbiological and epidemiological investigations to identify the aetiological agent in patients presenting with fever and diarrhoea.

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KW - Animals

KW - Bacterial Proteins/genetics

KW - Case-Control Studies

KW - Chickens/microbiology

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KW - Feces/microbiology

KW - Female

KW - Fever/epidemiology

KW - Food Contamination

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KW - Hemorrhagic Fever, Ebola/epidemiology

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KW - Shigella boydii/classification

KW - Sierra Leone/epidemiology

KW - United Kingdom/epidemiology

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KW - Young Adult

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SN - 0022-2615

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SP - 1596

EP - 1600

JO - Journal of Medical Microbiology

JF - Journal of Medical Microbiology

IS - 11

ER -

An outbreak of Shigella boydii serotype 20 in January 2015 amongst United Kingdom healthcare workers involved in the Ebola response in Sierra Leone

Abstract

UN SDGs

Keywords

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