Amygdala protein kinase C epsilon controls alcohol consumption

H M B Lesscher, M J Wallace, L Zeng, V Wang, J K Deitchman, T McMahon, R O Messing, P M Newton

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    Alcoholism is a progressive disorder that involves the amygdala. Mice lacking protein kinase C epsilon (PKCepsilon) show reduced ethanol consumption, sensitivity and reward. We therefore investigated whether PKCepsilon signaling in the amygdala is involved in ethanol consumption. Local knockdown of PKCepsilon in the amygdala reduced ethanol consumption and preference in a limited-access paradigm. Further, mice that are heterozygous for the PKCepsilon allele consume less ethanol compared with wild-type mice in this paradigm. These mice have a >50% reduction in the abundance of PKCepsilon in the amygdala compared with wild-type mice. We conclude that amygdala PKCepsilon is important for ethanol consumption in mice.

    Original languageEnglish
    Pages (from-to)493-9
    Number of pages7
    JournalGenes, Brain, and Behavior
    Volume8
    Issue number5
    DOIs
    Publication statusPublished - Jul 2009

    Keywords

    • Alcohol-Induced Disorders, Nervous System
    • Alcoholism
    • Amygdala
    • Animals
    • Brain Chemistry
    • Central Nervous System Depressants
    • Conditioning (Psychology)
    • Disease Models, Animal
    • Ethanol
    • Gene Frequency
    • Genetic Predisposition to Disease
    • Male
    • Mice
    • Mice, Inbred C57BL
    • Mice, Knockout
    • Protein Kinase C-epsilon
    • Reward

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