Amsterdam cohort study on HIV and AIDS: Impact of exposure to UVR as estimated by means of a 2-year retrospective questionnaire on immune parameters in HIV positive males

Jaap Maas; Fabian Termorshuizen; Ronald B. Geskus; Wim Goettsch; Roel A. Coutinho; Frank Miedema; Henk Van Loveren

doi:10.1078/1438-4639-00171

Amsterdam cohort study on HIV and AIDS: Impact of exposure to UVR as estimated by means of a 2-year retrospective questionnaire on immune parameters in HIV positive males

Jaap Maas
, Fabian Termorshuizen
, Ronald B. Geskus
, Wim Goettsch
, Roel A. Coutinho
, Frank Miedema
, Henk Van Loveren^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We studied a group of HIV-infected homosexuals who participated in the Amsterdam Cohort Study on HIV and AIDS to investigate whether greater exposure to sunlight is associated with a less favorable course of some important immunological parameters. This was done because ultraviolet radiation (UVR) is potentially harmful to the cellular immunity and may enhance viral replication. The exposure to UVR was estimated by means of a 2-year retrospective questionnaire in 1997. Both a 2-year cumulative estimate and estimates by 3-monthly episodes were calculated. The associations with CD4⁺ T-cell count, CD4⁺/CD8⁺ T-cell ratio, and T-cell reactivity were investigated. First, the associations between the cumulative estimate and the individual slopes of these parameters during the 2 years covered by the questionnaire were explored by means of a robust regression analysis. Secondly, the short-term association with the estimate by episode was examined by means of a linear mixed-effect model for repeated measurements (LME). No statistically significant associations with the cumulative estimate were found. Although a trend to lower values of the immunological parameters studied after short-term greater exposure in the LME model was observed, the differences were not statistically significant either. These findings suggest that exposure to sunlight does not have a suppressive effect on the above mentioned immunological parameters in HIV-infected persons.

Original language	English
Pages (from-to)	373-377
Number of pages	5
Journal	International Journal of Hygiene and Environmental Health
Volume	205
Issue number	5
DOIs	https://doi.org/10.1078/1438-4639-00171
Publication status	Published - 2002
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgements. This study was supported by the Dutch Foundation for Preventive Medicine (Grant No. 28-2370) as an initiative of the Dutch Program Committee for AIDS Research (PccAo), by EU Project ENV-4-CT96-0192, and by the Dutch National Research Program on Global Air Pollution and Climate Change (NOP, Project 952276). This study was performed as part of the Amsterdam Cohort study on HIV infection and AIDS, a collaboration between the Municipal Health Service, the University Medical Centre Amsterdam, the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service (CLB), the Sanquin Blood Supply Foundation and the Laboratory for Experimental and Clinical Immunology, Amsterdam, The Netherlands. We would like to thank N. Albrecht and M. Dekker for the daily organisation of the cohort study. Most of all, we are indebted to the men in the cohort for participating so willingly and so long.

Funding

Acknowledgements. This study was supported by the Dutch Foundation for Preventive Medicine (Grant No. 28-2370) as an initiative of the Dutch Program Committee for AIDS Research (PccAo), by EU Project ENV-4-CT96-0192, and by the Dutch National Research Program on Global Air Pollution and Climate Change (NOP, Project 952276). This study was performed as part of the Amsterdam Cohort study on HIV infection and AIDS, a collaboration between the Municipal Health Service, the University Medical Centre Amsterdam, the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service (CLB), the Sanquin Blood Supply Foundation and the Laboratory for Experimental and Clinical Immunology, Amsterdam, The Netherlands. We would like to thank N. Albrecht and M. Dekker for the daily organisation of the cohort study. Most of all, we are indebted to the men in the cohort for participating so willingly and so long.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Disease progression
HIV
Immunological parameters
Ultraviolet radiation

Access to Document

10.1078/1438-4639-00171

Cite this

Maas, J., Termorshuizen, F., Geskus, R. B., Goettsch, W., Coutinho, R. A., Miedema, F., & Van Loveren, H. (2002). Amsterdam cohort study on HIV and AIDS: Impact of exposure to UVR as estimated by means of a 2-year retrospective questionnaire on immune parameters in HIV positive males. International Journal of Hygiene and Environmental Health, 205(5), 373-377. https://doi.org/10.1078/1438-4639-00171

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title = "Amsterdam cohort study on HIV and AIDS: Impact of exposure to UVR as estimated by means of a 2-year retrospective questionnaire on immune parameters in HIV positive males",

abstract = "We studied a group of HIV-infected homosexuals who participated in the Amsterdam Cohort Study on HIV and AIDS to investigate whether greater exposure to sunlight is associated with a less favorable course of some important immunological parameters. This was done because ultraviolet radiation (UVR) is potentially harmful to the cellular immunity and may enhance viral replication. The exposure to UVR was estimated by means of a 2-year retrospective questionnaire in 1997. Both a 2-year cumulative estimate and estimates by 3-monthly episodes were calculated. The associations with CD4+ T-cell count, CD4+/CD8+ T-cell ratio, and T-cell reactivity were investigated. First, the associations between the cumulative estimate and the individual slopes of these parameters during the 2 years covered by the questionnaire were explored by means of a robust regression analysis. Secondly, the short-term association with the estimate by episode was examined by means of a linear mixed-effect model for repeated measurements (LME). No statistically significant associations with the cumulative estimate were found. Although a trend to lower values of the immunological parameters studied after short-term greater exposure in the LME model was observed, the differences were not statistically significant either. These findings suggest that exposure to sunlight does not have a suppressive effect on the above mentioned immunological parameters in HIV-infected persons.",

keywords = "Disease progression, HIV, Immunological parameters, Ultraviolet radiation",

author = "Jaap Maas and Fabian Termorshuizen and Geskus, \{Ronald B.\} and Wim Goettsch and Coutinho, \{Roel A.\} and Frank Miedema and \{Van Loveren\}, Henk",

note = "Funding Information: Acknowledgements. This study was supported by the Dutch Foundation for Preventive Medicine (Grant No. 28-2370) as an initiative of the Dutch Program Committee for AIDS Research (PccAo), by EU Project ENV-4-CT96-0192, and by the Dutch National Research Program on Global Air Pollution and Climate Change (NOP, Project 952276). This study was performed as part of the Amsterdam Cohort study on HIV infection and AIDS, a collaboration between the Municipal Health Service, the University Medical Centre Amsterdam, the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service (CLB), the Sanquin Blood Supply Foundation and the Laboratory for Experimental and Clinical Immunology, Amsterdam, The Netherlands. We would like to thank N. Albrecht and M. Dekker for the daily organisation of the cohort study. Most of all, we are indebted to the men in the cohort for participating so willingly and so long.",

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doi = "10.1078/1438-4639-00171",

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Maas, J, Termorshuizen, F, Geskus, RB, Goettsch, W, Coutinho, RA, Miedema, F & Van Loveren, H 2002, 'Amsterdam cohort study on HIV and AIDS: Impact of exposure to UVR as estimated by means of a 2-year retrospective questionnaire on immune parameters in HIV positive males', International Journal of Hygiene and Environmental Health, vol. 205, no. 5, pp. 373-377. https://doi.org/10.1078/1438-4639-00171

Amsterdam cohort study on HIV and AIDS: Impact of exposure to UVR as estimated by means of a 2-year retrospective questionnaire on immune parameters in HIV positive males. / Maas, Jaap; Termorshuizen, Fabian; Geskus, Ronald B. et al.
In: International Journal of Hygiene and Environmental Health, Vol. 205, No. 5, 2002, p. 373-377.

Research output: Contribution to journal › Article › Academic › peer-review

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T2 - Impact of exposure to UVR as estimated by means of a 2-year retrospective questionnaire on immune parameters in HIV positive males

AU - Maas, Jaap

AU - Termorshuizen, Fabian

AU - Geskus, Ronald B.

AU - Goettsch, Wim

AU - Coutinho, Roel A.

AU - Miedema, Frank

AU - Van Loveren, Henk

N1 - Funding Information: Acknowledgements. This study was supported by the Dutch Foundation for Preventive Medicine (Grant No. 28-2370) as an initiative of the Dutch Program Committee for AIDS Research (PccAo), by EU Project ENV-4-CT96-0192, and by the Dutch National Research Program on Global Air Pollution and Climate Change (NOP, Project 952276). This study was performed as part of the Amsterdam Cohort study on HIV infection and AIDS, a collaboration between the Municipal Health Service, the University Medical Centre Amsterdam, the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service (CLB), the Sanquin Blood Supply Foundation and the Laboratory for Experimental and Clinical Immunology, Amsterdam, The Netherlands. We would like to thank N. Albrecht and M. Dekker for the daily organisation of the cohort study. Most of all, we are indebted to the men in the cohort for participating so willingly and so long.

PY - 2002

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N2 - We studied a group of HIV-infected homosexuals who participated in the Amsterdam Cohort Study on HIV and AIDS to investigate whether greater exposure to sunlight is associated with a less favorable course of some important immunological parameters. This was done because ultraviolet radiation (UVR) is potentially harmful to the cellular immunity and may enhance viral replication. The exposure to UVR was estimated by means of a 2-year retrospective questionnaire in 1997. Both a 2-year cumulative estimate and estimates by 3-monthly episodes were calculated. The associations with CD4+ T-cell count, CD4+/CD8+ T-cell ratio, and T-cell reactivity were investigated. First, the associations between the cumulative estimate and the individual slopes of these parameters during the 2 years covered by the questionnaire were explored by means of a robust regression analysis. Secondly, the short-term association with the estimate by episode was examined by means of a linear mixed-effect model for repeated measurements (LME). No statistically significant associations with the cumulative estimate were found. Although a trend to lower values of the immunological parameters studied after short-term greater exposure in the LME model was observed, the differences were not statistically significant either. These findings suggest that exposure to sunlight does not have a suppressive effect on the above mentioned immunological parameters in HIV-infected persons.

AB - We studied a group of HIV-infected homosexuals who participated in the Amsterdam Cohort Study on HIV and AIDS to investigate whether greater exposure to sunlight is associated with a less favorable course of some important immunological parameters. This was done because ultraviolet radiation (UVR) is potentially harmful to the cellular immunity and may enhance viral replication. The exposure to UVR was estimated by means of a 2-year retrospective questionnaire in 1997. Both a 2-year cumulative estimate and estimates by 3-monthly episodes were calculated. The associations with CD4+ T-cell count, CD4+/CD8+ T-cell ratio, and T-cell reactivity were investigated. First, the associations between the cumulative estimate and the individual slopes of these parameters during the 2 years covered by the questionnaire were explored by means of a robust regression analysis. Secondly, the short-term association with the estimate by episode was examined by means of a linear mixed-effect model for repeated measurements (LME). No statistically significant associations with the cumulative estimate were found. Although a trend to lower values of the immunological parameters studied after short-term greater exposure in the LME model was observed, the differences were not statistically significant either. These findings suggest that exposure to sunlight does not have a suppressive effect on the above mentioned immunological parameters in HIV-infected persons.

KW - Disease progression

KW - HIV

KW - Immunological parameters

KW - Ultraviolet radiation

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SN - 1438-4639

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JO - International Journal of Hygiene and Environmental Health

JF - International Journal of Hygiene and Environmental Health

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ER -

Amsterdam cohort study on HIV and AIDS: Impact of exposure to UVR as estimated by means of a 2-year retrospective questionnaire on immune parameters in HIV positive males

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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