Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE)

Bénédicte Jacquemin; Valérie Siroux; Margaux Sanchez; Anne-Elie Carsin; Tamara Schikowski; Martin Adam; Valeria Bellisario; Anna Buschka; Roberto Bono; Bert Brunekreef; Yutong Cai; Marta Cirach; Françoise Clavel-Chapelon; Christophe Declercq; Roberto de Marco; Audrey de Nazelle; Regina E Ducret-Stich; Virginia Valeria Ferretti; Margaret W Gerbase; Rebecca Hardy; Joachim Heinrich; Christer Janson; Deborah Jarvis; Zaina Al Kanaani; Dirk Keidel; Diana Kuh; Nicole Le Moual; Mark J Nieuwenhuijsen; Alessandro Marcon; Lars Modig; Isabelle Pin; Thierry Rochat; Christian Schindler; Dorothea Sugiri; Morgane Stempfelet; Sofia Temam; Ming-Yi Tsai; Raphaëlle Varraso; Danielle Vienneau; Andrea Vierkötter; Anna L Hansell; Ursula Krämer; Nicole M Probst-Hensch; Jordi Sunyer; Nino Künzli; Francine Kauffmann

doi:10.1289/ehp.1408206

Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE)

Bénédicte Jacquemin, Valérie Siroux, Margaux Sanchez, Anne-Elie Carsin, Tamara Schikowski, Martin Adam, Valeria Bellisario, Anna Buschka, Roberto Bono, Bert Brunekreef, Yutong Cai, Marta Cirach, Françoise Clavel-Chapelon, Christophe Declercq, Roberto de Marco, Audrey de Nazelle, Regina E Ducret-Stich, Virginia Valeria Ferretti, Margaret W Gerbase, Rebecca HardyJoachim Heinrich, Christer Janson, Deborah Jarvis, Zaina Al Kanaani, Dirk Keidel, Diana Kuh, Nicole Le Moual, Mark J Nieuwenhuijsen, Alessandro Marcon, Lars Modig, Isabelle Pin, Thierry Rochat, Christian Schindler, Dorothea Sugiri, Morgane Stempfelet, Sofia Temam, Ming-Yi Tsai, Raphaëlle Varraso, Danielle Vienneau, Andrea Vierkötter, Anna L Hansell, Ursula Krämer, Nicole M Probst-Hensch, Jordi Sunyer, Nino Künzli, Francine Kauffmann

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear.

OBJECTIVE: We aimed to investigate the association between air pollution and adult onset asthma.

METHODS: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect.

RESULTS: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10-5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative association was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m3).

CONCLUSIONS: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed.

Original language	English
Pages (from-to)	613-21
Number of pages	9
Journal	Environmental Health Perspectives
Volume	123
Issue number	6
DOIs	https://doi.org/10.1289/ehp.1408206
Publication status	Published - Jun 2015

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Jacquemin, B., Siroux, V., Sanchez, M., Carsin, A.-E., Schikowski, T., Adam, M., Bellisario, V., Buschka, A., Bono, R., Brunekreef, B., Cai, Y., Cirach, M., Clavel-Chapelon, F., Declercq, C., de Marco, R., de Nazelle, A., Ducret-Stich, R. E., Ferretti, V. V., Gerbase, M. W., ... Kauffmann, F. (2015). Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE). Environmental Health Perspectives, 123(6), 613-21. https://doi.org/10.1289/ehp.1408206

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title = "Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE)",

abstract = "BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear.OBJECTIVE: We aimed to investigate the association between air pollution and adult onset asthma.METHODS: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect.RESULTS: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95\% CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95\% CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95\% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95\% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95\% CI: 0.95, 1.19 per 10-5/m), traffic load (adjusted OR = 1.10; 95\% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95\% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative association was estimated for PMcoarse (adjusted OR = 0.98; 95\% CI: 0.87, 1.14 per 5 μg/m3).CONCLUSIONS: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed.",

author = "B{\'e}n{\'e}dicte Jacquemin and Val{\'e}rie Siroux and Margaux Sanchez and Anne-Elie Carsin and Tamara Schikowski and Martin Adam and Valeria Bellisario and Anna Buschka and Roberto Bono and Bert Brunekreef and Yutong Cai and Marta Cirach and Fran{\c c}oise Clavel-Chapelon and Christophe Declercq and \{de Marco\}, Roberto and \{de Nazelle\}, Audrey and Ducret-Stich, \{Regina E\} and Ferretti, \{Virginia Valeria\} and Gerbase, \{Margaret W\} and Rebecca Hardy and Joachim Heinrich and Christer Janson and Deborah Jarvis and \{Al Kanaani\}, Zaina and Dirk Keidel and Diana Kuh and \{Le Moual\}, Nicole and Nieuwenhuijsen, \{Mark J\} and Alessandro Marcon and Lars Modig and Isabelle Pin and Thierry Rochat and Christian Schindler and Dorothea Sugiri and Morgane Stempfelet and Sofia Temam and Ming-Yi Tsai and Rapha{\"e}lle Varraso and Danielle Vienneau and Andrea Vierk{\"o}tter and Hansell, \{Anna L\} and Ursula Kr{\"a}mer and Probst-Hensch, \{Nicole M\} and Jordi Sunyer and Nino K{\"u}nzli and Francine Kauffmann",

year = "2015",

month = jun,

doi = "10.1289/ehp.1408206",

language = "English",

volume = "123",

pages = "613--21",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

publisher = "Public Health Services, US Dept of Health and Human Services",

number = "6",

}

Jacquemin, B, Siroux, V, Sanchez, M, Carsin, A-E, Schikowski, T, Adam, M, Bellisario, V, Buschka, A, Bono, R, Brunekreef, B, Cai, Y, Cirach, M, Clavel-Chapelon, F, Declercq, C, de Marco, R, de Nazelle, A, Ducret-Stich, RE, Ferretti, VV, Gerbase, MW, Hardy, R, Heinrich, J, Janson, C, Jarvis, D, Al Kanaani, Z, Keidel, D, Kuh, D, Le Moual, N, Nieuwenhuijsen, MJ, Marcon, A, Modig, L, Pin, I, Rochat, T, Schindler, C, Sugiri, D, Stempfelet, M, Temam, S, Tsai, M-Y, Varraso, R, Vienneau, D, Vierkötter, A, Hansell, AL, Krämer, U, Probst-Hensch, NM, Sunyer, J, Künzli, N & Kauffmann, F 2015, 'Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE)', Environmental Health Perspectives, vol. 123, no. 6, pp. 613-21. https://doi.org/10.1289/ehp.1408206

TY - JOUR

T1 - Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE)

AU - Jacquemin, Bénédicte

AU - Siroux, Valérie

AU - Sanchez, Margaux

AU - Carsin, Anne-Elie

AU - Schikowski, Tamara

AU - Adam, Martin

AU - Bellisario, Valeria

AU - Buschka, Anna

AU - Bono, Roberto

AU - Brunekreef, Bert

AU - Cai, Yutong

AU - Cirach, Marta

AU - Clavel-Chapelon, Françoise

AU - Declercq, Christophe

AU - de Marco, Roberto

AU - de Nazelle, Audrey

AU - Ducret-Stich, Regina E

AU - Ferretti, Virginia Valeria

AU - Gerbase, Margaret W

AU - Hardy, Rebecca

AU - Heinrich, Joachim

AU - Janson, Christer

AU - Jarvis, Deborah

AU - Al Kanaani, Zaina

AU - Keidel, Dirk

AU - Kuh, Diana

AU - Le Moual, Nicole

AU - Nieuwenhuijsen, Mark J

AU - Marcon, Alessandro

AU - Modig, Lars

AU - Pin, Isabelle

AU - Rochat, Thierry

AU - Schindler, Christian

AU - Sugiri, Dorothea

AU - Stempfelet, Morgane

AU - Temam, Sofia

AU - Tsai, Ming-Yi

AU - Varraso, Raphaëlle

AU - Vienneau, Danielle

AU - Vierkötter, Andrea

AU - Hansell, Anna L

AU - Krämer, Ursula

AU - Probst-Hensch, Nicole M

AU - Sunyer, Jordi

AU - Künzli, Nino

AU - Kauffmann, Francine

PY - 2015/6

Y1 - 2015/6

N2 - BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear.OBJECTIVE: We aimed to investigate the association between air pollution and adult onset asthma.METHODS: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect.RESULTS: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10-5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative association was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m3).CONCLUSIONS: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed.

AB - BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear.OBJECTIVE: We aimed to investigate the association between air pollution and adult onset asthma.METHODS: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect.RESULTS: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10-5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative association was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m3).CONCLUSIONS: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed.

U2 - 10.1289/ehp.1408206

DO - 10.1289/ehp.1408206

M3 - Article

C2 - 25712593

SN - 0091-6765

VL - 123

SP - 613

EP - 621

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 6

ER -

Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE)

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