Aligned assembly in a 2-D gel of a water-soluble peptide

Zainab O.  Makinde; Nadine van der Heijden; Laura J.  Domigan; Duncan J. McGillivray; David E.  Williams

doi:10.1021/acs.langmuir.0c01944

Aligned assembly in a 2-D gel of a water-soluble peptide

Zainab O. Makinde, Nadine van der Heijden, Laura J. Domigan, Duncan J. McGillivray, David E. Williams

Afd Natuurkunde Algemeen

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We demonstrate the assembly of a compact, gel-like Langmuir–Blodgett film of rods formed by self-assembly of a β-sheet-forming water-soluble peptide, Ac-IKHLSVN-NH2, at the surface of aqueous electrolytes. We characterize surface pressure hysteresis and demonstrate shear stiffening of the surface caused by area cycling, which we interpret as due to rearrangement and alignment of the rods. We show strong effects of the electrolyte on the assembly of the elementary rods, which can be related to the Hofmeister series and interpreted by effects on the interaction energies mediated by ions and water. Formation of β-sheet structures and assembly of these into surface-segregated semicrystalline gels was strongly promoted by ammonium sulfate electrolyte. With ammonium sulfate electrolyte as subphase for Langmuir–Blodgett film deposition, shear stiffening by surface area cycling resulted in very compact films on transfer to a substrate.

Original language	English
Pages (from-to)	11292-11302
Journal	Langmuir
Volume	36
Issue number	38
DOIs	https://doi.org/10.1021/acs.langmuir.0c01944
Publication status	Published - 2020

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title = "Aligned assembly in a 2-D gel of a water-soluble peptide",

abstract = "We demonstrate the assembly of a compact, gel-like Langmuir–Blodgett film of rods formed by self-assembly of a β-sheet-forming water-soluble peptide, Ac-IKHLSVN-NH2, at the surface of aqueous electrolytes. We characterize surface pressure hysteresis and demonstrate shear stiffening of the surface caused by area cycling, which we interpret as due to rearrangement and alignment of the rods. We show strong effects of the electrolyte on the assembly of the elementary rods, which can be related to the Hofmeister series and interpreted by effects on the interaction energies mediated by ions and water. Formation of β-sheet structures and assembly of these into surface-segregated semicrystalline gels was strongly promoted by ammonium sulfate electrolyte. With ammonium sulfate electrolyte as subphase for Langmuir–Blodgett film deposition, shear stiffening by surface area cycling resulted in very compact films on transfer to a substrate.",

author = "Makinde, {Zainab O.} and {van der Heijden}, Nadine and Domigan, {Laura J.} and McGillivray, {Duncan J.} and Williams, {David E.}",

year = "2020",

doi = "10.1021/acs.langmuir.0c01944",

language = "English",

volume = "36",

pages = "11292--11302",

journal = "Langmuir",

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TY - JOUR

T1 - Aligned assembly in a 2-D gel of a water-soluble peptide

AU - Makinde, Zainab O.

AU - van der Heijden, Nadine

AU - Domigan, Laura J.

AU - McGillivray, Duncan J.

AU - Williams, David E.

PY - 2020

Y1 - 2020

N2 - We demonstrate the assembly of a compact, gel-like Langmuir–Blodgett film of rods formed by self-assembly of a β-sheet-forming water-soluble peptide, Ac-IKHLSVN-NH2, at the surface of aqueous electrolytes. We characterize surface pressure hysteresis and demonstrate shear stiffening of the surface caused by area cycling, which we interpret as due to rearrangement and alignment of the rods. We show strong effects of the electrolyte on the assembly of the elementary rods, which can be related to the Hofmeister series and interpreted by effects on the interaction energies mediated by ions and water. Formation of β-sheet structures and assembly of these into surface-segregated semicrystalline gels was strongly promoted by ammonium sulfate electrolyte. With ammonium sulfate electrolyte as subphase for Langmuir–Blodgett film deposition, shear stiffening by surface area cycling resulted in very compact films on transfer to a substrate.

AB - We demonstrate the assembly of a compact, gel-like Langmuir–Blodgett film of rods formed by self-assembly of a β-sheet-forming water-soluble peptide, Ac-IKHLSVN-NH2, at the surface of aqueous electrolytes. We characterize surface pressure hysteresis and demonstrate shear stiffening of the surface caused by area cycling, which we interpret as due to rearrangement and alignment of the rods. We show strong effects of the electrolyte on the assembly of the elementary rods, which can be related to the Hofmeister series and interpreted by effects on the interaction energies mediated by ions and water. Formation of β-sheet structures and assembly of these into surface-segregated semicrystalline gels was strongly promoted by ammonium sulfate electrolyte. With ammonium sulfate electrolyte as subphase for Langmuir–Blodgett film deposition, shear stiffening by surface area cycling resulted in very compact films on transfer to a substrate.

U2 - 10.1021/acs.langmuir.0c01944

DO - 10.1021/acs.langmuir.0c01944

M3 - Article

SN - 0743-7463

VL - 36

SP - 11292

EP - 11302

JO - Langmuir

JF - Langmuir

IS - 38

ER -

Aligned assembly in a 2-D gel of a water-soluble peptide

Abstract

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