Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort

Susan Peters; Valentina Gallo; Paolo Vineis; Lefkos T Middleton; Lars Forsgren; Carlotta Sacerdote; Sabina Sieri; Andreas Kyrozis; María-Dolores Chirlaque; Raul Zamora-Ros; Oskar Hansson; Jesper Petersson; Verena Katzke; Tilman Kühn; Olatz Mokoroa; Giovanna Masala; Eva Ardanaz; Salvatore Panico; Manuela M Bergmann; Timothy J Key; Elisabete Weiderpass; Pietro Ferrari; Roel Vermeulen

doi:10.1002/mds.28039

Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort

Susan Peters, Valentina Gallo, Paolo Vineis, Lefkos T Middleton, Lars Forsgren, Carlotta Sacerdote, Sabina Sieri, Andreas Kyrozis, María-Dolores Chirlaque, Raul Zamora-Ros, Oskar Hansson, Jesper Petersson, Verena Katzke, Tilman Kühn, Olatz Mokoroa, Giovanna Masala, Eva Ardanaz, Salvatore Panico, Manuela M Bergmann, Timothy J KeyElisabete Weiderpass, Pietro Ferrari, Roel Vermeulen

IRAS OH Epidemiology Chemical Agents

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive.

OBJECTIVE: To assess the associations between alcohol consumption and PD risk.

METHODS: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence.

RESULTS: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD.

CONCLUSION: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Original language	English
Pages (from-to)	1258-1263
Journal	Movement Disorders
Volume	35
Issue number	7
Early online date	2020
DOIs	https://doi.org/10.1002/mds.28039
Publication status	Published - Jul 2020

Keywords

alcohol
EPIC
epidemiology
Parkinson
prospective cohort

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Peters, S., Gallo, V., Vineis, P., Middleton, L. T., Forsgren, L., Sacerdote, C., Sieri, S., Kyrozis, A., Chirlaque, M.-D., Zamora-Ros, R., Hansson, O., Petersson, J., Katzke, V., Kühn, T., Mokoroa, O., Masala, G., Ardanaz, E., Panico, S., Bergmann, M. M., ... Vermeulen, R. (2020). Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort. Movement Disorders, 35(7), 1258-1263. https://doi.org/10.1002/mds.28039

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title = "Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort",

abstract = "BACKGROUND: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive.OBJECTIVE: To assess the associations between alcohol consumption and PD risk.METHODS: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence.RESULTS: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD.CONCLUSION: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. {\textcopyright} 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.",

keywords = "alcohol, EPIC, epidemiology, Parkinson, prospective cohort",

author = "Susan Peters and Valentina Gallo and Paolo Vineis and Middleton, {Lefkos T} and Lars Forsgren and Carlotta Sacerdote and Sabina Sieri and Andreas Kyrozis and Mar{\'i}a-Dolores Chirlaque and Raul Zamora-Ros and Oskar Hansson and Jesper Petersson and Verena Katzke and Tilman K{\"u}hn and Olatz Mokoroa and Giovanna Masala and Eva Ardanaz and Salvatore Panico and Bergmann, {Manuela M} and Key, {Timothy J} and Elisabete Weiderpass and Pietro Ferrari and Roel Vermeulen",

note = "{\textcopyright} 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.",

year = "2020",

month = jul,

doi = "10.1002/mds.28039",

language = "English",

volume = "35",

pages = "1258--1263",

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issn = "0885-3185",

publisher = "John Wiley & Sons Inc.",

number = "7",

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Peters, S, Gallo, V, Vineis, P, Middleton, LT, Forsgren, L, Sacerdote, C, Sieri, S, Kyrozis, A, Chirlaque, M-D, Zamora-Ros, R, Hansson, O, Petersson, J, Katzke, V, Kühn, T, Mokoroa, O, Masala, G, Ardanaz, E, Panico, S, Bergmann, MM, Key, TJ, Weiderpass, E, Ferrari, P & Vermeulen, R 2020, 'Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort', Movement Disorders, vol. 35, no. 7, pp. 1258-1263. https://doi.org/10.1002/mds.28039

TY - JOUR

T1 - Alcohol Consumption and Risk of Parkinson's Disease

T2 - Data from a Large Prospective European Cohort

AU - Peters, Susan

AU - Gallo, Valentina

AU - Vineis, Paolo

AU - Middleton, Lefkos T

AU - Forsgren, Lars

AU - Sacerdote, Carlotta

AU - Sieri, Sabina

AU - Kyrozis, Andreas

AU - Chirlaque, María-Dolores

AU - Zamora-Ros, Raul

AU - Hansson, Oskar

AU - Petersson, Jesper

AU - Katzke, Verena

AU - Kühn, Tilman

AU - Mokoroa, Olatz

AU - Masala, Giovanna

AU - Ardanaz, Eva

AU - Panico, Salvatore

AU - Bergmann, Manuela M

AU - Key, Timothy J

AU - Weiderpass, Elisabete

AU - Ferrari, Pietro

AU - Vermeulen, Roel

PY - 2020/7

Y1 - 2020/7

N2 - BACKGROUND: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive.OBJECTIVE: To assess the associations between alcohol consumption and PD risk.METHODS: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence.RESULTS: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD.CONCLUSION: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

AB - BACKGROUND: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive.OBJECTIVE: To assess the associations between alcohol consumption and PD risk.METHODS: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence.RESULTS: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD.CONCLUSION: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

KW - alcohol

KW - EPIC

KW - epidemiology

KW - Parkinson

KW - prospective cohort

U2 - 10.1002/mds.28039

DO - 10.1002/mds.28039

M3 - Article

C2 - 32357270

SN - 0885-3185

VL - 35

SP - 1258

EP - 1263

JO - Movement Disorders

JF - Movement Disorders

IS - 7

ER -

Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort

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Keywords

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