Air pollution: metabolites and respiratory health across the life-course

Olena Gruzieva; Ayoung Jeong; Shizhen He; Zhebin Yu; Jeroen de Bont; Maria G M Pinho; Ikenna C Eze; Sara Kress; Craig E Wheelock; Annette Peters; Jelle Vlaanderen; Kees de Hoogh; Augustin Scalbert; Marc Chadeau-Hyam; Roel C H Vermeulen; Ulrike Gehring; Nicole Probst-Hensch; Erik Melén

doi:10.1183/16000617.0038-2022

Air pollution: metabolites and respiratory health across the life-course

Olena Gruzieva
, Ayoung Jeong
, Shizhen He
, Zhebin Yu
, Jeroen de Bont
, Maria G M Pinho
, Ikenna C Eze
, Sara Kress
, Craig E Wheelock
, Annette Peters
, Jelle Vlaanderen
, Kees de Hoogh
, Augustin Scalbert
, Marc Chadeau-Hyam
, Roel C H Vermeulen
, Ulrike Gehring
, Nicole Probst-Hensch
, Erik Melén

IRAS OH Epidemiology Chemical Agents

Karolinska Institutet
Swiss Tropical and Public Health Institute
Dept of Epidemiology and Data Science
c IUF - Leibniz Research Institute for Environmental Medicine , Düsseldorf , Germany.
Institute of Epidemiology II
Nutrition and Metabolism Branch
Utrecht University of Applied Sciences
University of Basel

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Previous studies have explored the relationships of air pollution and metabolic profiles with lung function. However, the metabolites linking air pollution and lung function and the associated mechanisms have not been reviewed from a life-course perspective. Here, we provide a narrative review summarising recent evidence on the associations of metabolic profiles with air pollution exposure and lung function in children and adults. Twenty-six studies identified through a systematic PubMed search were included with 10 studies analysing air pollution-related metabolic profiles and 16 studies analysing lung function-related metabolic profiles. A wide range of metabolites were associated with short- and long-term exposure, partly overlapping with those linked to lung function in the general population and with respiratory diseases such as asthma and COPD. The existing studies show that metabolomics offers the potential to identify biomarkers linked to both environmental exposures and respiratory outcomes, but many studies suffer from small sample sizes, cross-sectional designs, a preponderance on adult lung function, heterogeneity in exposure assessment, lack of confounding control and omics integration. The ongoing EXposome Powered tools for healthy living in urbAN Settings (EXPANSE) project aims to address some of these shortcomings by combining biospecimens from large European cohorts and harmonised air pollution exposure and exposome data.

Original language	English
Article number	220038
Number of pages	12
Journal	European Respiratory Review
Volume	31
Issue number	165
Early online date	10 Aug 2022
DOIs	https://doi.org/10.1183/16000617.0038-2022
Publication status	Published - 30 Sept 2022

Bibliographical note

Funding Information:
Conflict of interest: M.G.M. Pinho reports a Leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid as an Associate editor at the journal Public Health Nutrition. C.E. Wheelock has received support for the present manuscript from Swedish Heart Lung Foundation. M. Chadeau-Hyam has shares in the OSMOSE consulting company; work performed in the company has no link with the present work. N. Probst-Hensch reports salary support from Swiss TPH Core Funds. The remaining authors have nothing to disclose.

Publisher Copyright:
© The authors 2022.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 11 Sustainable Cities and Communities

Keywords

Adult
Air Pollutants/adverse effects
Air Pollution/adverse effects
Child
Cross-Sectional Studies
Environmental Exposure/adverse effects
Humans
Particulate Matter

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10.1183/16000617.0038-2022Licence: CC BY-NC

220038.full (1)Final published version, 959 KBLicence: CC BY-NC

Cite this

Gruzieva, O., Jeong, A., He, S., Yu, Z., de Bont, J., Pinho, M. G. M., Eze, I. C., Kress, S., Wheelock, C. E., Peters, A., Vlaanderen, J., de Hoogh, K., Scalbert, A., Chadeau-Hyam, M., Vermeulen, R. C. H., Gehring, U., Probst-Hensch, N., & Melén, E. (2022). Air pollution: metabolites and respiratory health across the life-course. European Respiratory Review, 31(165), Article 220038. https://doi.org/10.1183/16000617.0038-2022

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abstract = "Previous studies have explored the relationships of air pollution and metabolic profiles with lung function. However, the metabolites linking air pollution and lung function and the associated mechanisms have not been reviewed from a life-course perspective. Here, we provide a narrative review summarising recent evidence on the associations of metabolic profiles with air pollution exposure and lung function in children and adults. Twenty-six studies identified through a systematic PubMed search were included with 10 studies analysing air pollution-related metabolic profiles and 16 studies analysing lung function-related metabolic profiles. A wide range of metabolites were associated with short- and long-term exposure, partly overlapping with those linked to lung function in the general population and with respiratory diseases such as asthma and COPD. The existing studies show that metabolomics offers the potential to identify biomarkers linked to both environmental exposures and respiratory outcomes, but many studies suffer from small sample sizes, cross-sectional designs, a preponderance on adult lung function, heterogeneity in exposure assessment, lack of confounding control and omics integration. The ongoing EXposome Powered tools for healthy living in urbAN Settings (EXPANSE) project aims to address some of these shortcomings by combining biospecimens from large European cohorts and harmonised air pollution exposure and exposome data.",

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note = "Funding Information: Conflict of interest: M.G.M. Pinho reports a Leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid as an Associate editor at the journal Public Health Nutrition. C.E. Wheelock has received support for the present manuscript from Swedish Heart Lung Foundation. M. Chadeau-Hyam has shares in the OSMOSE consulting company; work performed in the company has no link with the present work. N. Probst-Hensch reports salary support from Swiss TPH Core Funds. The remaining authors have nothing to disclose. Publisher Copyright: {\textcopyright} The authors 2022.",

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Gruzieva, O, Jeong, A, He, S, Yu, Z, de Bont, J, Pinho, MGM, Eze, IC, Kress, S, Wheelock, CE, Peters, A, Vlaanderen, J , de Hoogh, K, Scalbert, A, Chadeau-Hyam, M, Vermeulen, RCH , Gehring, U, Probst-Hensch, N & Melén, E 2022, 'Air pollution: metabolites and respiratory health across the life-course', European Respiratory Review, vol. 31, no. 165, 220038. https://doi.org/10.1183/16000617.0038-2022

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AU - Gruzieva, Olena

AU - Jeong, Ayoung

AU - He, Shizhen

AU - Yu, Zhebin

AU - de Bont, Jeroen

AU - Pinho, Maria G M

AU - Eze, Ikenna C

AU - Kress, Sara

AU - Wheelock, Craig E

AU - Peters, Annette

AU - Vlaanderen, Jelle

AU - de Hoogh, Kees

AU - Scalbert, Augustin

AU - Chadeau-Hyam, Marc

AU - Vermeulen, Roel C H

AU - Gehring, Ulrike

AU - Probst-Hensch, Nicole

AU - Melén, Erik

N1 - Funding Information: Conflict of interest: M.G.M. Pinho reports a Leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid as an Associate editor at the journal Public Health Nutrition. C.E. Wheelock has received support for the present manuscript from Swedish Heart Lung Foundation. M. Chadeau-Hyam has shares in the OSMOSE consulting company; work performed in the company has no link with the present work. N. Probst-Hensch reports salary support from Swiss TPH Core Funds. The remaining authors have nothing to disclose. Publisher Copyright: © The authors 2022.

PY - 2022/9/30

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N2 - Previous studies have explored the relationships of air pollution and metabolic profiles with lung function. However, the metabolites linking air pollution and lung function and the associated mechanisms have not been reviewed from a life-course perspective. Here, we provide a narrative review summarising recent evidence on the associations of metabolic profiles with air pollution exposure and lung function in children and adults. Twenty-six studies identified through a systematic PubMed search were included with 10 studies analysing air pollution-related metabolic profiles and 16 studies analysing lung function-related metabolic profiles. A wide range of metabolites were associated with short- and long-term exposure, partly overlapping with those linked to lung function in the general population and with respiratory diseases such as asthma and COPD. The existing studies show that metabolomics offers the potential to identify biomarkers linked to both environmental exposures and respiratory outcomes, but many studies suffer from small sample sizes, cross-sectional designs, a preponderance on adult lung function, heterogeneity in exposure assessment, lack of confounding control and omics integration. The ongoing EXposome Powered tools for healthy living in urbAN Settings (EXPANSE) project aims to address some of these shortcomings by combining biospecimens from large European cohorts and harmonised air pollution exposure and exposome data.

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KW - Air Pollutants/adverse effects

KW - Air Pollution/adverse effects

KW - Child

KW - Cross-Sectional Studies

KW - Environmental Exposure/adverse effects

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KW - Particulate Matter

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M1 - 220038

ER -

Air pollution: metabolites and respiratory health across the life-course

Abstract

Bibliographical note

UN SDGs

Keywords

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