Air-liquid interface exposure of in vitro lung models:improvement and application to study 
inhalation toxicity of aircraft-related air pollutants

Ruiwen He

doi:10.33540/108

Air-liquid interface exposure of in vitro lung models:improvement and application to study inhalation toxicity of aircraft-related air pollutants

Ruiwen He

IRAS OH Toxicology

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Abstract

We optimize in vitro lung models under prolonged ALI culture conditions for investigating the adverse health effects of air pollutants that are emitted by and in aircrafts.We found that exposure to aircraft-related air pollutants, airport UFPs and the generated cabin fumes, can induce considerable lung toxicity, highlighting their potential inhalation risks under real-life exposure conditions.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Utrecht University
Supervisors/Advisors	Cassee, Flemming, Primary supervisor Westerink, Remco, Co-supervisor
Award date	14 Sept 2021
Publisher	Utrecht University
DOIs	https://doi.org/10.33540/108
Publication status	Published - 14 Sept 2021

Keywords

Aerosol exposures
Co-culture
Epithelial cells
Macrophages
Air–liquid interface
Barrier function
UFPs
Airport emission
Aircraft cabin air

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10.33540/108Licence: CC BY-ND

Air-liquid interface exposure of in vitro lung models:improvement and application to study inhalation toxicity of aircraft-related air pollutantsFinal published version, 11.1 MB

https://dspace.library.uu.nl/handle/1874/404931

Cite this

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title = "Air-liquid interface exposure of in vitro lung models:improvement and application to study inhalation toxicity of aircraft-related air pollutants",

abstract = "We optimize in vitro lung models under prolonged ALI culture conditions for investigating the adverse health effects of air pollutants that are emitted by and in aircrafts.We found that exposure to aircraft-related air pollutants, airport UFPs and the generated cabin fumes, can induce considerable lung toxicity, highlighting their potential inhalation risks under real-life exposure conditions.",

keywords = "Aerosol exposures, Co-culture, Epithelial cells, Macrophages, Air–liquid interface, Barrier function, UFPs, Airport emission, Aircraft cabin air",

author = "Ruiwen He",

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type = "Doctoral thesis 1 (Research UU / Graduation UU)",

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N2 - We optimize in vitro lung models under prolonged ALI culture conditions for investigating the adverse health effects of air pollutants that are emitted by and in aircrafts.We found that exposure to aircraft-related air pollutants, airport UFPs and the generated cabin fumes, can induce considerable lung toxicity, highlighting their potential inhalation risks under real-life exposure conditions.

AB - We optimize in vitro lung models under prolonged ALI culture conditions for investigating the adverse health effects of air pollutants that are emitted by and in aircrafts.We found that exposure to aircraft-related air pollutants, airport UFPs and the generated cabin fumes, can induce considerable lung toxicity, highlighting their potential inhalation risks under real-life exposure conditions.

KW - Aerosol exposures

KW - Co-culture

KW - Epithelial cells

KW - Macrophages

KW - Air–liquid interface

KW - Barrier function

KW - UFPs

KW - Airport emission

KW - Aircraft cabin air

U2 - 10.33540/108

DO - 10.33540/108

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

PB - Utrecht University

ER -

Air-liquid interface exposure of in vitro lung models:improvement and application to study inhalation toxicity of aircraft-related air pollutants

Abstract

Keywords

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