Adverse Outcome Pathways Mechanistically Describing Hepatotoxicity

Ellen Callewaert, Jochem Louisse, Nynke Kramer, Julen Sanz-Serrano, Mathieu Vinken*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Adverse outcome pathways (AOPs) describe toxicological processes from a dynamic perspective by linking a molecular initiating event to a specific adverse outcome via a series of key events and key event relationships. In the field of computational toxicology, AOPs can potentially facilitate the design and development of in silico prediction models for hazard identification. Various AOPs have been introduced for several types of hepatotoxicity, such as steatosis, cholestasis, fibrosis, and liver cancer. This chapter provides an overview of AOPs on hepatotoxicity, including their development, assessment, and applications in toxicology.

Original languageEnglish
Title of host publicationComputational Toxicology
Subtitle of host publicationMethods and Protocols
EditorsOrazio Nicolotti
Place of PublicationNew York
PublisherHumana Press
Chapter12
Pages249-273
Number of pages25
Edition2
ISBN (Electronic)978-1-0716-4003-6
ISBN (Print)978-1-0716-4002-9, 978-1-0716-4005-0
DOIs
Publication statusPublished - 24 Sept 2024

Publication series

NameMethods in Molecular Biology
PublisherHumana
Volume2834
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Bibliographical note

Publisher Copyright:
© The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2025.

Keywords

  • AOP
  • Cancer
  • Cholestasis
  • Fibrosis
  • Liver toxicity
  • Steatosis

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