Abstract
The effects of all-trans-retinoic acid were investigated on the immune responses in B57Bl/6 mice after daily oral administration for one week. In selected experiments the immunosuppressive chemicals, cyclophosphamide and cyclosporin A were used in conjuntion with retinoic acid. Retinoic acid stimulated the production of antibodies against sheep red blood cells and DNP - Ficoll; however, retinoic acid did not reverse the depression caused by immunosuppressive chemicals. In non-immunized animals retinoic acid stimulated the production of IL-1 but not of IL-2. The mitogenic responses of splenocytes against concanavalin A, phytohemagglutinin and pokeweed mitogen were depressed after the retinoic acid treatment; those against lipopolysaccharide were not influenced. Treatment with retinoic acid did not alter the mixed leukocyte responses but increased the activity of NK cells. Results indicated that retinoic acid may act as an adjuvant via activating macrophages, however, retinoic acid cannot reverse the immunosuppression induced by potent chemicals.
| Original language | English |
|---|---|
| Pages (from-to) | 143-150 |
| Number of pages | 8 |
| Journal | International Journal of Immunopharmacology |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1992 |
| Externally published | Yes |
Bibliographical note
Funding Information:Acknowledgements -- The authors gratefully acknowledge the gift of cyclosporin A by Sandoz Research Institute, East Hanover, NJ. This research was supported in part by HD28259 and Utah State University Agriculture Experiment Station and is published as Journal Paper No. 4132.
Funding
Acknowledgements -- The authors gratefully acknowledge the gift of cyclosporin A by Sandoz Research Institute, East Hanover, NJ. This research was supported in part by HD28259 and Utah State University Agriculture Experiment Station and is published as Journal Paper No. 4132.