Abstract
The existence of an HO-3...O-5' intramolecular hydrogen bond in methyl β-cellobioside in solution in Me2SO-d6and H2O-CD3OD (4:1 w/w) was studied by 500-MHz1H-NMR spectroscopy and MD simulations. Temperature coefficients for the chemical shift of the hydroxyl resonances in these solvents were determined and the rates of proton exchange in the latter solvent were obtained from NOE data. With H2O-CD3OD as the solvent, the HO-3...O-5' hydrogen bond was insignificant, but its presence in Me2SO-d6was confirmed.
Original language | English |
---|---|
Pages (from-to) | 41-61 |
Number of pages | 21 |
Journal | Carbohydrate Research |
Volume | 230 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jun 1992 |
Keywords
- cellobioside
- glycoside
- unclassified drug
- article
- chemical structure
- mathematics
- nuclear magnetic resonance
- theory