A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity

Adinda Kok; Samuel H Wilks; Sina Tureli; Sarah L James; Theo M Bestebroer; David F Burke; Mathis Funk; Stefan van der Vliet; Monique I Spronken; Willemijn F Rijnink; David Pattinson; Dennis de Meulder; Miruna E Rosu; Pascal Lexmond; Judith M A van den Brand; Sander Herfst; Derek J Smith; Ron A M Fouchier; Mathilde Richard

doi:10.1101/2024.08.06.606696

A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity

Adinda Kok
, Samuel H Wilks
, Sina Tureli
, Sarah L James
, Theo M Bestebroer
, David F Burke
, Mathis Funk
, Stefan van der Vliet
, Monique I Spronken
, Willemijn F Rijnink
, David Pattinson
, Dennis de Meulder
, Miruna E Rosu
, Pascal Lexmond
, Judith M A van den Brand
, Sander Herfst
, Derek J Smith
, Ron A M Fouchier
, Mathilde Richard^*

^*Corresponding author for this work

Research output: Working paper › Preprint › Academic

Abstract

Highly pathogenic avian influenza A(H5) viruses globally impact wild and domestic birds, and mammals, including humans, underscoring their pandemic potential. The antigenic evolution of the A(H5) hemagglutinin (HA) poses challenges for pandemic preparedness and vaccine design. Here, the global antigenic evolution of the A(H5) HA was captured in a high-resolution antigenic map. The map was used to engineer immunogenic and antigenically central vaccine HA antigens, eliciting antibody responses that broadly cover the A(H5) antigenic space. In ferrets, a central antigen protected as well as homologous vaccines against heterologous infection with two antigenically distinct viruses. This work showcases the rational design of subtype-wide influenza A(H5) pre-pandemic vaccines and demonstrates the value of antigenic maps for the evaluation of vaccine-induced immune responses through antibody profiles.

Original language	English
Publisher	bioRxiv
Number of pages	26
DOIs	https://doi.org/10.1101/2024.08.06.606696
Publication status	Published - 6 Aug 2024

Publication series

Name	bioRxiv
Publisher	Cold Spring Harbor Laboratory
ISSN (Print)	2692-8205

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1101/2024.08.06.606696Licence: CC BY

2024.08.06.606696v1.fullSubmitted manuscript, 685 KBLicence: CC BY

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Kok, A., Wilks, S. H., Tureli, S., James, S. L., Bestebroer, T. M., Burke, D. F., Funk, M., van der Vliet, S., Spronken, M. I., Rijnink, W. F., Pattinson, D., de Meulder, D., Rosu, M. E., Lexmond, P., van den Brand, J. M. A., Herfst, S., Smith, D. J., Fouchier, R. A. M., & Richard, M. (2024). A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity. (bioRxiv). bioRxiv. https://doi.org/10.1101/2024.08.06.606696

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title = "A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity",

abstract = "Highly pathogenic avian influenza A(H5) viruses globally impact wild and domestic birds, and mammals, including humans, underscoring their pandemic potential. The antigenic evolution of the A(H5) hemagglutinin (HA) poses challenges for pandemic preparedness and vaccine design. Here, the global antigenic evolution of the A(H5) HA was captured in a high-resolution antigenic map. The map was used to engineer immunogenic and antigenically central vaccine HA antigens, eliciting antibody responses that broadly cover the A(H5) antigenic space. In ferrets, a central antigen protected as well as homologous vaccines against heterologous infection with two antigenically distinct viruses. This work showcases the rational design of subtype-wide influenza A(H5) pre-pandemic vaccines and demonstrates the value of antigenic maps for the evaluation of vaccine-induced immune responses through antibody profiles.",

author = "Adinda Kok and Wilks, \{Samuel H\} and Sina Tureli and James, \{Sarah L\} and Bestebroer, \{Theo M\} and Burke, \{David F\} and Mathis Funk and \{van der Vliet\}, Stefan and Spronken, \{Monique I\} and Rijnink, \{Willemijn F\} and David Pattinson and \{de Meulder\}, Dennis and Rosu, \{Miruna E\} and Pascal Lexmond and \{van den Brand\}, \{Judith M A\} and Sander Herfst and Smith, \{Derek J\} and Fouchier, \{Ron A M\} and Mathilde Richard",

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Kok, A, Wilks, SH, Tureli, S, James, SL, Bestebroer, TM, Burke, DF, Funk, M, van der Vliet, S, Spronken, MI, Rijnink, WF, Pattinson, D, de Meulder, D, Rosu, ME, Lexmond, P, van den Brand, JMA, Herfst, S, Smith, DJ, Fouchier, RAM & Richard, M 2024 'A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity' bioRxiv, bioRxiv. https://doi.org/10.1101/2024.08.06.606696

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AU - Funk, Mathis

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AU - de Meulder, Dennis

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AU - Lexmond, Pascal

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A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity

Abstract

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