TY - UNPB
T1 - A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity
AU - Kok, Adinda
AU - Wilks, Samuel H
AU - Tureli, Sina
AU - James, Sarah L
AU - Bestebroer, Theo M
AU - Burke, David F
AU - Funk, Mathis
AU - van der Vliet, Stefan
AU - Spronken, Monique I
AU - Rijnink, Willemijn F
AU - Pattinson, David
AU - de Meulder, Dennis
AU - Rosu, Miruna E
AU - Lexmond, Pascal
AU - van den Brand, Judith M A
AU - Herfst, Sander
AU - Smith, Derek J
AU - Fouchier, Ron A M
AU - Richard, Mathilde
PY - 2024/8/6
Y1 - 2024/8/6
N2 - Highly pathogenic avian influenza A(H5) viruses globally impact wild and domestic birds, and mammals, including humans, underscoring their pandemic potential. The antigenic evolution of the A(H5) hemagglutinin (HA) poses challenges for pandemic preparedness and vaccine design. Here, the global antigenic evolution of the A(H5) HA was captured in a high-resolution antigenic map. The map was used to engineer immunogenic and antigenically central vaccine HA antigens, eliciting antibody responses that broadly cover the A(H5) antigenic space. In ferrets, a central antigen protected as well as homologous vaccines against heterologous infection with two antigenically distinct viruses. This work showcases the rational design of subtype-wide influenza A(H5) pre-pandemic vaccines and demonstrates the value of antigenic maps for the evaluation of vaccine-induced immune responses through antibody profiles.
AB - Highly pathogenic avian influenza A(H5) viruses globally impact wild and domestic birds, and mammals, including humans, underscoring their pandemic potential. The antigenic evolution of the A(H5) hemagglutinin (HA) poses challenges for pandemic preparedness and vaccine design. Here, the global antigenic evolution of the A(H5) HA was captured in a high-resolution antigenic map. The map was used to engineer immunogenic and antigenically central vaccine HA antigens, eliciting antibody responses that broadly cover the A(H5) antigenic space. In ferrets, a central antigen protected as well as homologous vaccines against heterologous infection with two antigenically distinct viruses. This work showcases the rational design of subtype-wide influenza A(H5) pre-pandemic vaccines and demonstrates the value of antigenic maps for the evaluation of vaccine-induced immune responses through antibody profiles.
U2 - 10.1101/2024.08.06.606696
DO - 10.1101/2024.08.06.606696
M3 - Preprint
C2 - 39553979
T3 - bioRxiv
BT - A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity
PB - bioRxiv
ER -