A two-directional approach for the solid-phase synthesis of trisaccharide libraries

Tong Zhu; Geert Jan Boons

doi:10.1002/(SICI)1521-3773(19980803)37:13/14<1898::AID-ANIE1898>3.0.CO;2-T

A two-directional approach for the solid-phase synthesis of trisaccharide libraries

Tong Zhu, Geert Jan Boons^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Without protecting groups, polymer-bound thioglycosyl sugars can undergo two successive glycosylation reactions, once as a donor and once as an acceptor, to give trisaccharides such as 1. Trisaccharide libraries prepared by this strategy have a known sugar residue at the reducing or nonreducing ends. · = polymer resin + amide linker.

Original language	English
Pages (from-to)	1898-1900
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	37
Issue number	13-14
DOIs	https://doi.org/10.1002/(SICI)1521-3773(19980803)37:13/14<1898::AID-ANIE1898>3.0.CO;2-T
Publication status	Published - 3 Aug 1998
Externally published	Yes

Keywords

Combinatorial chemistry
Glycosylations
Oligosaccharides
Solid-phase synthesis

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10.1002/(SICI)1521-3773(19980803)37:13/14<1898::AID-ANIE1898>3.0.CO;2-T

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abstract = "Without protecting groups, polymer-bound thioglycosyl sugars can undergo two successive glycosylation reactions, once as a donor and once as an acceptor, to give trisaccharides such as 1. Trisaccharide libraries prepared by this strategy have a known sugar residue at the reducing or nonreducing ends. · = polymer resin + amide linker.",

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year = "1998",

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AB - Without protecting groups, polymer-bound thioglycosyl sugars can undergo two successive glycosylation reactions, once as a donor and once as an acceptor, to give trisaccharides such as 1. Trisaccharide libraries prepared by this strategy have a known sugar residue at the reducing or nonreducing ends. · = polymer resin + amide linker.

KW - Combinatorial chemistry

KW - Glycosylations

KW - Oligosaccharides

KW - Solid-phase synthesis

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ER -

A two-directional approach for the solid-phase synthesis of trisaccharide libraries

Abstract

Keywords

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