A two-directional and highly convergent approach for the synthesis of the tumor-associated antigen Globo-H

Tong Zhu; Geert Jan Boons

doi:10.1002/(SICI)1521-3773(19991203)38:23<3495::AID-ANIE3495>3.0.CO;2-X

A two-directional and highly convergent approach for the synthesis of the tumor-associated antigen Globo-H

Tong Zhu
, Geert Jan Boons^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The assembly of six readily available building blocks in five glycosylation steps affords the tumor-associated Globo-H hexasaccharide 1 without the need for any intermediate protecting group manipulations. The aminopropyl spacer is employed for conjugation to carrier proteins.

Original language	English
Pages (from-to)	3495-3497
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	38
Issue number	23
DOIs	https://doi.org/10.1002/(SICI)1521-3773(19991203)38:23<3495::AID-ANIE3495>3.0.CO;2-X
Publication status	Published - 3 Dec 1999
Externally published	Yes

Keywords

Antigens
Chemoselectivity
Glycosylations
Oligosaccharides

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10.1002/(SICI)1521-3773(19991203)38:23<3495::AID-ANIE3495>3.0.CO;2-X

Cite this

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title = "A two-directional and highly convergent approach for the synthesis of the tumor-associated antigen Globo-H",

abstract = "The assembly of six readily available building blocks in five glycosylation steps affords the tumor-associated Globo-H hexasaccharide 1 without the need for any intermediate protecting group manipulations. The aminopropyl spacer is employed for conjugation to carrier proteins.",

keywords = "Antigens, Chemoselectivity, Glycosylations, Oligosaccharides",

author = "Tong Zhu and Boons, \{Geert Jan\}",

year = "1999",

month = dec,

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doi = "10.1002/(SICI)1521-3773(19991203)38:23<3495::AID-ANIE3495>3.0.CO;2-X",

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AU - Zhu, Tong

AU - Boons, Geert Jan

PY - 1999/12/3

Y1 - 1999/12/3

N2 - The assembly of six readily available building blocks in five glycosylation steps affords the tumor-associated Globo-H hexasaccharide 1 without the need for any intermediate protecting group manipulations. The aminopropyl spacer is employed for conjugation to carrier proteins.

AB - The assembly of six readily available building blocks in five glycosylation steps affords the tumor-associated Globo-H hexasaccharide 1 without the need for any intermediate protecting group manipulations. The aminopropyl spacer is employed for conjugation to carrier proteins.

KW - Antigens

KW - Chemoselectivity

KW - Glycosylations

KW - Oligosaccharides

U2 - 10.1002/(SICI)1521-3773(19991203)38:23<3495::AID-ANIE3495>3.0.CO;2-X

DO - 10.1002/(SICI)1521-3773(19991203)38:23<3495::AID-ANIE3495>3.0.CO;2-X

M3 - Article

AN - SCOPUS:0033521192

SN - 1433-7851

VL - 38

SP - 3495

EP - 3497

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 23

ER -

A two-directional and highly convergent approach for the synthesis of the tumor-associated antigen Globo-H

Abstract

Keywords

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