TY - JOUR
T1 - A systematic review of the proposed mechanisms underpinning pain relief by primary motor cortex stimulation in animals
AU - Henssen, Dylan
AU - Giesen, Esmay
AU - van der Heiden, Maudy
AU - Kerperien, Mijke
AU - Lange, Sibylle
AU - van Cappellen van Walsum, Anne Marie
AU - Kurt, Erkan
AU - van Dongen, Robert
AU - Schutter, Dennis
AU - Vissers, Kris
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/2/6
Y1 - 2020/2/6
N2 - Experimental treatments for treating neuropathic pain include transcranial magnetic stimulation (TMS) and invasive electric motor cortex stimulation (iMCS) of the primary motor cortex (M1). Mechanisms of action of both methods, however, remain largely elusive. Within this paper, we focus on animal-based experiments in order to investigate the biological mechanisms that are involved in alleviating pain by use of TMS and/or iMCS. Therefore, this paper systematically reviewed the animal-based evidence on these mechanisms. Multiple online databases were systematically searched and retrieved articles were assessed using predefined inclusion and exclusion criteria. Twenty-three suitable articles were included; six on TMS and seventeen on iMCS. In general, iMCS and TMS were found to impact the primary motor cortex structure and function in animals. Furthermore, structural and functional changes within the thalamus, striatum, periaqueductal grey, rostral ventromedial medulla and dorsal horn were reported to occur. Although widespread, all areas in which structural and functional changes occurred after TMS and iMCS have been found to be interconnected anatomically. This could provide a rationale for future investigations of treating neuropathic pain by use of neuromodulation.
AB - Experimental treatments for treating neuropathic pain include transcranial magnetic stimulation (TMS) and invasive electric motor cortex stimulation (iMCS) of the primary motor cortex (M1). Mechanisms of action of both methods, however, remain largely elusive. Within this paper, we focus on animal-based experiments in order to investigate the biological mechanisms that are involved in alleviating pain by use of TMS and/or iMCS. Therefore, this paper systematically reviewed the animal-based evidence on these mechanisms. Multiple online databases were systematically searched and retrieved articles were assessed using predefined inclusion and exclusion criteria. Twenty-three suitable articles were included; six on TMS and seventeen on iMCS. In general, iMCS and TMS were found to impact the primary motor cortex structure and function in animals. Furthermore, structural and functional changes within the thalamus, striatum, periaqueductal grey, rostral ventromedial medulla and dorsal horn were reported to occur. Although widespread, all areas in which structural and functional changes occurred after TMS and iMCS have been found to be interconnected anatomically. This could provide a rationale for future investigations of treating neuropathic pain by use of neuromodulation.
KW - Animals
KW - Chronic neuropathic pain
KW - Motor cortex
KW - Motor cortex stimulation
KW - Neuromodulation
KW - Physiology
KW - Transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=85072274357&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2019.134489
DO - 10.1016/j.neulet.2019.134489
M3 - Review article
C2 - 31518678
AN - SCOPUS:85072274357
SN - 0304-3940
VL - 719
JO - Neuroscience Letters
JF - Neuroscience Letters
M1 - 134489
ER -